HSFY1
Heat shock transcription factor, Y-linked
Also known as: FLJ25453, HSF2L, HSFY, HSFY1_HUMAN, HSFY2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96LI6
- Gene
- HSFY1
- Ensembl
- ENSG00000172468
- Chromosome
- Y
- Canonical length
- 401 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
This gene encodes a member of the heat shock factor (HSF) family of transcriptional activators for heat shock proteins. This gene is a candidate gene for azoospermia, since it localizes to a region of chromosome Y that is sometimes deleted in infertile males. The genome has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
401 residues, UniProt reviewed canonical sequence.
>Q96LI6|HSFY1
1 MAHVSSETQD VSPKDELTAS EASTRSPLCE HTFPGDSDLR SMIEEHAFQV LSQGSLLESP
61 SYTVCVSEPD KDDDFLSLNF PRKLWKIVES DQFKSISWDE NGTCIVINEE LFKKEILETK
121 APYRIFQTDA IKSFVRQLNL YGFSKIQQNF QRSAFLATFL SEEKESSVLS KLKFYYNPNF
181 KRGYPQLLVR VKRRIGVKNA SPISTLFNED FNKKHFRAGA NMENHNSALA AEASEESLFS
241 ASKNLNMPLT RESSVRQIIA NSSVPIRSGF PPPSPSTSVG PSEQIATDQH AILNQLTTIH
301 MHSHSTYMQA RGHIVNFITT TTSQYHIISP LQNGYFGLTV EPSAVPTRYP LVSVNEAPYR
361 NMLPAGNPWL QMPTIADRSA APHSRLALQP SPLDKYHPNY NLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HSFY1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 20 nTPM
Expression across tissuesHPA
Tissue
- testis: 20 nTPM
- hypothalamus: 0.6 nTPM
- cerebellum: 0.4 nTPM
- cerebral cortex: 0.4 nTPM
- hippocampal formation: 0.3 nTPM
- amygdala: 0.2 nTPM
Single-cell type
- papillary tip epithelial cells: 0.4 nCPM
- podocytes: 0.3 nCPM
- proximal tubule cells: 0.3 nCPM
- distal convoluted tubule cells: 0.2 nCPM
- renal connecting tubule cells: 0.2 nCPM
- early spermatids: 0.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 2.4 nTPM
- white matter: 1.9 nTPM
- hypothalamus: 1.4 nTPM
- pons: 1.2 nTPM
- medulla oblongata: 1.1 nTPM
- basal ganglia: 0.9 nTPM
OntologyGO
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of HSFY1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HSFY1 as an antibody target. Whether an autoantibody or antibody against HSFY1 could matter depends on whether native HSFY1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HSFY1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HSFY1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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