Seroatlas · Human Serome Atlas

HSFX4

Heat shock transcription factor, X-linked member 4

Also known as: HSFX4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A1B0GTS1
Gene: HSFX4
Ensembl: ENSG00000283463
Chromosome: X
Canonical length: 333 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>A0A1B0GTS1|HSFX4
     1  MASQNTEQEY EAKLAPSVGG EPTSGGPSGS SPDPNPDSSE VLDRHEDQAM SQDPGSQDNS
    61  PPEDRNQRVV NVEDNHNLFR LSFPRKLWTI VEEDTFKSVS WNDDGDAVII DKDLFQREVL
   121  QRKGAERIFK TDNLTSFIRQ LNLYGFCKTR PSNSPGNKKM MIYCNSNFQR DKPRLLENIQ
   181  RKDALRNTAQ QATRVPTPKR KNLVATRRSL RIYHINARKE AIKMCQQGAP SVQGPSGTQS
   241  FRRSGMWSKK SATRHPLGNG PPQEPNGPSW EGTSGNVTFT SSATTWMEGT GILSSLVYSD
   301  NGSVMSLYNI CYYALLASLS VMSPNEPSDD EEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSFX4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
adrenal gland: 2.6 nTPM
ovary: 0.4 nTPM
heart muscle: 0.2 nTPM
liver: 0.2 nTPM
pancreas: 0.2 nTPM

Single-cell type

late primary spermatocytes: 134 nCPM
early spermatids: 122 nCPM
late spermatids: 16 nCPM
epicardial cells: 4.5 nCPM
sertoli cells: 1.7 nCPM
urothelial cells: 1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 2 nTPM
cerebral cortex: 1.4 nTPM
pons: 1.2 nTPM
choroid plexus: 1 nTPM
white matter: 0.9 nTPM
basal ganglia: 0.8 nTPM

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSFX4 as an antibody target. Whether an autoantibody or antibody against HSFX4 could matter depends on whether native HSFX4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSFX4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSFX4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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