Seroatlas · Human Serome Atlas

PCID2

PCI domain-containing protein 2

Also known as: FLJ11305, PCID2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5JVF3
Gene
PCID2
Ensembl
ENSG00000126226
Chromosome
13
Canonical length
399 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>Q5JVF3|PCID2
     1  MAHITINQYL QQVYEAIDSR DGASCAELVS FKHPHVANPR LQMASPEEKC QQVLEPPYDE
    61  MFAAHLRCTY AVGNHDFIEA YKCQTVIVQS FLRAFQAHKE ENWALPVMYA VALDLRVFAN
   121  NADQQLVKKG KSKVGDMLEK AAELLMSCFR VCASDTRAGI EDSKKWGMLF LVNQLFKIYF
   181  KINKLHLCKP LIRAIDSSNL KDDYSTAQRV TYKYYVGRKA MFDSDFKQAE EYLSFAFEHC
   241  HRSSQKNKRM ILIYLLPVKM LLGHMPTVEL LKKYHLMQFA EVTRAVSEGN LLLLHEALAK
   301  HEAFFIRCGI FLILEKLKII TYRNLFKKVY LLLKTHQLSL DAFLVALKFM QVEDVDIDEV
   361  QCILANLIYM GHVKGYISHQ HQKLVVSKQN PFPPLSTVC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCID2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • testis: 42 nTPM
  • heart muscle: 35 nTPM
  • ovary: 32 nTPM
  • adrenal gland: 29 nTPM
  • skeletal muscle: 28 nTPM
  • cerebellum: 27 nTPM

Single-cell type

  • oocytes: 304 nCPM
  • late primary spermatocytes: 297 nCPM
  • early primary spermatocytes: 134 nCPM
  • differentiating spermatogonia: 93 nCPM
  • prostatic glandular cells: 68 nCPM
  • myosatellite cells: 67 nCPM

Immune cell

  • MAIT T-cell: 82 nTPM
  • memory CD8 T-cell: 73 nTPM
  • gdT-cell: 69 nTPM
  • T-reg: 65 nTPM
  • memory CD4 T-cell: 58 nTPM
  • naive CD8 T-cell: 55 nTPM

Brain region

  • cerebellum: 14 nTPM
  • white matter: 14 nTPM
  • choroid plexus: 13 nTPM
  • hypothalamus: 11 nTPM
  • cerebral cortex: 11 nTPM
  • thalamus: 9.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
1.56
DepMap mean gene effect
-1.32
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PCID2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCID2 as an antibody target. Whether an autoantibody or antibody against PCID2 could matter depends on whether native PCID2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCID2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCID2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PCID2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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