Seroatlas · Human Serome Atlas

DVL2

Segment polarity protein dishevelled homolog DVL-2

Also known as: DVL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14641
Gene
DVL2
Ensembl
ENSG00000004975
Chromosome
17
Canonical length
736 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Aggresome

OverviewNCBI Gene

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

736 residues, UniProt reviewed canonical sequence.

>O14641|DVL2
     1  MAGSSTGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP AGAKYFFKSM
    61  DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA PPVHEPRAEL APPAPPLPPL
   121  PPERTSGIGD SRPPSFHPNV SSSHENLEPE TETESVVSLR RERPRRRDSS EHGAGGHRTG
   181  GPSRLERHLA GYESSSTLMT SELESTSLGD SDEEDTMSRF SSSTEQSSAS RLLKRHRRRR
   241  KQRPPRLERT SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM
   301  KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT VAKCWDPSPQ
   361  AYFTLPRNEP IQPIDPAAWV SHSAALTGTF PAYPGSSSMS TITSGSSLPD GCEGRGLSVH
   421  TDMASVTKAM AAPESGLEVR DRMWLKITIP NAFLGSDVVD WLYHHVEGFP ERREARKYAS
   481  GLLKAGLIRH TVNKITFSEQ CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP
   541  GATPWPLLPT FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG
   601  AGRTGRPEER APESKSGSGS ESEPSSRGGS LRRGGEASGT SDGGPPPSRG STGGAPNLRA
   661  HPGLHPYGPP PGMALPYNPM MVVMMPPPPP PVPPAVQPPG APPVRDLGSV PPELTASRQS
   721  FHMAMGNPSE FFVDVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DVL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 33 nTPM
  • cervix: 31 nTPM
  • endometrium: 29 nTPM
  • skin: 28 nTPM
  • pituitary gland: 25 nTPM
  • vagina: 25 nTPM

Single-cell type

  • syncytiotrophoblasts: 48 nCPM
  • differentiating spermatogonia: 44 nCPM
  • esophageal apical cells: 41 nCPM
  • esophageal suprabasal cells: 29 nCPM
  • esophageal basal cells: 29 nCPM
  • adrenal cortex cells: 28 nCPM

Immune cell

  • basophil: 14 nTPM
  • eosinophil: 10 nTPM
  • gdT-cell: 10 nTPM
  • naive B-cell: 9.3 nTPM
  • memory CD8 T-cell: 9 nTPM
  • memory B-cell: 8.6 nTPM

Brain region

  • white matter: 24 nTPM
  • cerebral cortex: 22 nTPM
  • medulla oblongata: 22 nTPM
  • basal ganglia: 21 nTPM
  • midbrain: 20 nTPM
  • thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0
gnomAD missense Z
0.32
DepMap mean gene effect
-0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DVL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DVL2 as an antibody target. Whether an autoantibody or antibody against DVL2 could matter depends on whether native DVL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DVL2 is annotated at the cell surface, where native DVL2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DVL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DVL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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