Seroatlas · Human Serome Atlas

DEPDC1B

DEP domain-containing protein 1B

Also known as: BRCC3, DEP1B_HUMAN, XTP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUY9
Gene: DEPDC1B
Ensembl: ENSG00000035499
Chromosome: 5
Canonical length: 529 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Involved in cell migration and positive regulation of Wnt signaling pathway. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

529 residues, UniProt reviewed canonical sequence.

>Q8WUY9|DEPDC1B
     1  MEHRIVGPGP YRATRLWNET VELFRAKMPL RKHRCRFKSY EHCFTAAEAV DWLHELLRCS
    61  QNFGPEVTRK QTVQLLKKFL KNHVIEDIKG KWGEEDFEDN RHLYRFPPSS PLKPYPKKPP
   121  NQKDVIKFPE WNDLPPGTSQ ENIPVRPVVM NSEMWYKRHS IAIGEVPACR LVHRRQLTEA
   181  NVEEIWKSMT LSYLQKILGL DSLEEVLDVK LVNSKFIIHN VYSVSKQGVV ILDDKSKELP
   241  HWVLSAMKCL ANWPNCSDLK QPMYLGFEKD VFKTIADYYG HLKEPLLTFH LFDAFVSVLG
   301  LLQKEKVAVE AFQICCLLLP PENRRKLQLL MRMMARICLN KEMPPLCDGF GTRTLMVQTF
   361  SRCILCSKDE VDLDELLAAR LVTFLMDNYQ EILKVPLALQ TSIEERVAHL RRVQIKYPGA
   421  DMDITLSAPS FCRQISPEEF EYQRSYGSQE PLAALLEEVI TDAKLSNKEK KKKLKQFQKS
   481  YPEVYQERFP TPESAALLFP EKPKPKPQLL MWALKKPFQP FQRTRSFRM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DEPDC1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

gallbladder: 20 nTPM
thymus: 19 nTPM
testis: 12 nTPM
bone marrow: 11 nTPM
tonsil: 9 nTPM
lymph node: 8.4 nTPM

Single-cell type

syncytiotrophoblasts: 192 nCPM
distal convoluted tubule cells: 151 nCPM
monocyte progenitors: 118 nCPM
endometrial luminal cells: 86 nCPM
neutrophil progenitors: 79 nCPM
erythrocyte progenitors: 75 nCPM

Immune cell

T-reg: 3.2 nTPM
basophil: 1.5 nTPM
memory CD4 T-cell: 1 nTPM
eosinophil: 0.9 nTPM
memory CD8 T-cell: 0.7 nTPM
NK-cell: 0.6 nTPM

Brain region

white matter: 2.7 nTPM
medulla oblongata: 2.6 nTPM
pons: 2.1 nTPM
basal ganglia: 1.3 nTPM
thalamus: 1.2 nTPM
spinal cord: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.85
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTPase activator activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DEPDC1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CDC23

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DEPDC1B as an antibody target. Whether an autoantibody or antibody against DEPDC1B could matter depends on whether native DEPDC1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DEPDC1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DEPDC1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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