Seroatlas · Human Serome Atlas

PARP12

Protein mono-ADP-ribosyltransferase PARP12

Also known as: ARTD12, FLJ22693, PAR12_HUMAN, PARP-12, ZC3H1, ZC3HDC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H0J9
Gene
PARP12
Ensembl
ENSG00000059378
Chromosome
7
Canonical length
701 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables NAD+-protein mono-ADP-ribosyltransferase activity. Involved in protein auto-ADP-ribosylation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

701 residues, UniProt reviewed canonical sequence.

>Q9H0J9|PARP12
     1  MAQAGVVGEV TQVLCAAGGA LELPELRRRL RMGLSADALE RLLRQRGRFV VAVRAGGAAA
    61  APERVVLAAS PLRLCRAHQG SKPGCVGLCA QLHLCRFMVY GACKFLRAGK NCRNSHSLTT
   121  EHNLSVLRTH GVDHLSYNEL CQLLFQNDPW LLPEICQHYN KGDGPHGSCA FQKQCIKLHI
   181  CQYFLQGECK FGTSCKRSHD FSNSENLEKL EKLGMSSDLV SRLPTIYRNA HDIKNKSSAP
   241  SRVPPLFVPQ GTSERKDSSG SVSPNTLSQE EGDQICLYHI RKSCSFQDKC HRVHFHLPYR
   301  WQFLDRGKWE DLDNMELIEE AYCNPKIERI LCSESASTFH SHCLNFNAMT YGATQARRLS
   361  TASSVTKPPH FILTTDWIWY WSDEFGSWQE YGRQGTVHPV TTVSSSDVEK AYLAYCTPGS
   421  DGQAATLKFQ AGKHNYELDF KAFVQKNLVY GTTKKVCRRP KYVSPQDVTT MQTCNTKFPG
   481  PKSIPDYWDS SALPDPGFQK ITLSSSSEEY QKVWNLFNRT LPFYFVQKIE RVQNLALWEV
   541  YQWQKGQMQK QNGGKAVDER QLFHGTSAIF VDAICQQNFD WRVCGVHGTS YGKGSYFARD
   601  AAYSHHYSKS DTQTHTMFLA RVLVGEFVRG NASFVRPPAK EGWSNAFYDS CVNSVSDPSI
   661  FVIFEKHQVY PEYVIQYTTS SKPSVTPSIL LALGSLFSSR Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARP12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 17 nTPM
  • small intestine: 17 nTPM
  • salivary gland: 16 nTPM
  • spleen: 16 nTPM
  • bone marrow: 15 nTPM
  • lung: 15 nTPM

Single-cell type

  • alveolar cells type 1: 84 nCPM
  • enterocytes: 52 nCPM
  • foveolar cells: 49 nCPM
  • early primary spermatocytes: 48 nCPM
  • neutrophil progenitors: 42 nCPM
  • colonocytes: 41 nCPM

Immune cell

  • non-classical monocyte: 6.4 nTPM
  • T-reg: 5.8 nTPM
  • intermediate monocyte: 5.5 nTPM
  • eosinophil: 4.3 nTPM
  • classical monocyte: 3 nTPM
  • naive B-cell: 2.5 nTPM

Brain region

  • medulla oblongata: 16 nTPM
  • spinal cord: 12 nTPM
  • pons: 10 nTPM
  • choroid plexus: 9.7 nTPM
  • white matter: 9.2 nTPM
  • thalamus: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
0.96
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PARP12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARP12 as an antibody target. Whether an autoantibody or antibody against PARP12 could matter depends on whether native PARP12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARP12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PARP12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PARP12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...