Seroatlas · Human Serome Atlas

TFDP2

Transcription factor Dp-2

Also known as: Dp-2, TFDP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14188
Gene: TFDP2
Ensembl: ENSG00000114126
Chromosome: 3
Canonical length: 446 aa
Protein class: Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles,Mitotic spindle

OverviewNCBI Gene

The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

446 residues, UniProt reviewed canonical sequence.

>Q14188|TFDP2
     1  MTAKNVGLTS TNAEVRGFID QNLSPTKGNI SFVAFPVSNT NSPTKILPKT LGPINVNVGP
    61  QMIISTPQRL TSSGSVLIGS PYTPAPAMVT QTHIAEATGW VPGDRKRARK FIDSDFSESK
   121  RSKKGDKNGK GLRHFSMKVC EKVQRKGTTS YNEVADELVS EFTNSNNHLA ADSAYDQKNI
   181  RRRVYDALNV LMAMNIISKE KKEIKWIGLP TNSAQECQNL EIEKQRRIER IKQKRAQLQE
   241  LLLQQIAFKN LVQRNRQNEQ QNQGPPALNS TIQLPFIIIN TSRKTVIDCS ISSDKFEYLF
   301  NFDNTFEIHD DIEVLKRMGM SFGLESGKCS LEDLKLAKSL VPKALEGYIT DISTGPSWLN
   361  QGLLLNSTQS VSNLDLTTGA TLPQSSVNQG LCLDAEVALA TGQFLAPNSH QSSSAASHCS
   421  ESRGETPCSF NDEDEEDDEE DSSSPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TFDP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 158 nTPM

Expression across tissuesHPA

Tissue

thymus: 158 nTPM
testis: 65 nTPM
bone marrow: 47 nTPM
kidney: 28 nTPM
skeletal muscle: 27 nTPM
placenta: 27 nTPM

Single-cell type

early spermatids: 1,042 nCPM
late primary spermatocytes: 802 nCPM
somatotrophs: 582 nCPM
proximal tubule cells: 560 nCPM
late spermatids: 505 nCPM
cytotrophoblasts: 474 nCPM

Immune cell

basophil: 70 nTPM
eosinophil: 48 nTPM
NK-cell: 38 nTPM
plasmacytoid DC: 34 nTPM
gdT-cell: 28 nTPM
naive CD8 T-cell: 22 nTPM

Brain region

cerebellum: 76 nTPM
cerebral cortex: 58 nTPM
pons: 58 nTPM
midbrain: 56 nTPM
medulla oblongata: 53 nTPM
white matter: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 1.69
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TFDP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TFDP2 as an antibody target. Whether an autoantibody or antibody against TFDP2 could matter depends on whether native TFDP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TFDP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TFDP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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