Seroatlas · Human Serome Atlas

ETV3

ETS translocation variant 3

Also known as: ETV3_HUMAN, PE-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P41162
Gene: ETV3
Ensembl: ENSG00000117036
Chromosome: 1
Canonical length: 512 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Vesicles,Cytosol

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

512 residues, UniProt reviewed canonical sequence.

>P41162|ETV3
     1  MKAGCSIVEK PEGGGGYQFP DWAYKTESSP GSRQIQLWHF ILELLQKEEF RHVIAWQQGE
    61  YGEFVIKDPD EVARLWGRRK CKPQMNYDKL SRALRYYYNK RILHKTKGKR FTYKFNFNKL
   121  VMPNYPFINI RSSGVVPQSA PPVPTASSRF HFPPLDTHSP TNDVQPGRFS ASSLTASGQE
   181  SSNGTDRKTE LSELEDGSAA DWRRGVDPVS SRNAIGGGGI GHQKRKPDIM LPLFARPGMY
   241  PDPHSPFAVS PIPGRGGVLN VPISPALSLT PTIFSYSPSP GLSPFTSSSC FSFNPEEMKH
   301  YLHSQACSVF NYHLSPRTFP RYPGLMVPPL QCQMHPEEST QFSIKLQPPP VGRKNRERVE
   361  SSEESAPVTT PTMASIPPRI KVEPASEKDP ESLRQSAREK EEHTQEEGTV PSRTIEEEKG
   421  TIFARPAAPP IWPSVPISTP SGEPLEVTED SEDRPGKEPS APEKKEDALM PPKLRLKRRW
   481  NDDPEARELS KSGKFLWNGS GPQGLATAAA DA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ETV3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

skin: 30 nTPM
bone marrow: 23 nTPM
parathyroid gland: 23 nTPM
urinary bladder: 16 nTPM
esophagus: 15 nTPM
duodenum: 14 nTPM

Single-cell type

cdc: 325 nCPM
ocular epithelial cells: 162 nCPM
urothelial cells: 157 nCPM
pdcs: 147 nCPM
epididymal basal cells: 132 nCPM
monocytes: 128 nCPM

Immune cell

basophil: 6.3 nTPM
MAIT T-cell: 6.2 nTPM
neutrophil: 5.4 nTPM
classical monocyte: 4.6 nTPM
gdT-cell: 4.5 nTPM
memory CD8 T-cell: 4.5 nTPM

Brain region

cerebral cortex: 46 nTPM
hypothalamus: 21 nTPM
hippocampal formation: 21 nTPM
medulla oblongata: 20 nTPM
cerebellum: 20 nTPM
thalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.98
gnomAD missense Z: 2.3
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ETV3 as an antibody target. Whether an autoantibody or antibody against ETV3 could matter depends on whether native ETV3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ETV3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ETV3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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