Seroatlas · Human Serome Atlas

FOXR2

Forkhead box protein R2

Also known as: FOXN6, FOXR2_HUMAN, MGC21658

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PJQ5
Gene: FOXR2
Ensembl: ENSG00000189299
Chromosome: X
Canonical length: 311 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

311 residues, UniProt reviewed canonical sequence.

>Q6PJQ5|FOXR2
     1  MDLKLKDCEF WYSLHGQVPG LLDWDMRNEL FLPCTTDQCS LAEQILAKYR VGVMKPPEMP
    61  QKRRPSPDGD GPPCEPNLWM WVDPNILCPL GSQEAPKPSG KEDLTNISPF PQPPQKDEGS
   121  NCSEDKVVES LPSSSSEQSP LQKQGIHSPS DFELTEEEAE EPDDNSLQSP EMKCYQSQKL
   181  WQINNQEKSW QRPPLNCSHL IALALRNNPH CGLSVQEIYN FTRQHFPFFW TAPDGWKSTI
   241  HYNLCFLDSF EKVPDSLKDE DNARPRSCLW KLTKEGHRRF WEETRVLAFA QRERIQECMS
   301  QPELLTSLFD L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 1.2 nTPM

Expression across tissuesHPA

Tissue

testis: 1.2 nTPM
epididymis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

sertoli cells: 5.9 nCPM
differentiating spermatogonia: 5.7 nCPM
early primary spermatocytes: 1.1 nCPM
undifferentiated spermatogonia: 0.6 nCPM
early spermatids: 0.2 nCPM
leydig cells: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0.08
gnomAD missense Z: -0.21
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOXR2 as an antibody target. Whether an autoantibody or antibody against FOXR2 could matter depends on whether native FOXR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOXR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOXR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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