Seroatlas · Human Serome Atlas

LACTB2

Endoribonuclease LACTB2

Also known as: CGI-83, LACB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53H82
Gene: LACTB2
Ensembl: ENSG00000147592
Chromosome: 8
Canonical length: 288 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables RNA endonuclease activity; single-stranded RNA binding activity; and zinc ion binding activity. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>Q53H82|LACTB2
     1  MAAVLQRVER LSNRVVRVLG CNPGPMTLQG TNTYLVGTGP RRILIDTGEP AIPEYISCLK
    61  QALTEFNTAI QEIVVTHWHR DHSGGIGDIC KSINNDTTYC IKKLPRNPQR EEIIGNGEQQ
   121  YVYLKDGDVI KTEGATLRVL YTPGHTDDHM ALLLEEENAI FSGDCILGEG TTVFEDLYDY
   181  MNSLKELLKI KADIIYPGHG PVIHNAEAKI QQYISHRNIR EQQILTLFRE NFEKSFTVME
   241  LVKIIYKNTP ENLHEMAKHN LLLHLKKLEK EGKIFSNTDP DKKWKAHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LACTB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 90 nTPM

Expression across tissuesHPA

Tissue

liver: 90 nTPM
kidney: 72 nTPM
testis: 59 nTPM
duodenum: 37 nTPM
adrenal gland: 36 nTPM
small intestine: 32 nTPM

Single-cell type

late primary spermatocytes: 666 nCPM
early spermatids: 251 nCPM
tuft cells: 173 nCPM
gastric progenitor cells: 138 nCPM
epididymal efferent duct absorptive cells: 124 nCPM
alveolar cells type 1: 115 nCPM

Immune cell

myeloid DC: 17 nTPM
intermediate monocyte: 17 nTPM
non-classical monocyte: 17 nTPM
basophil: 16 nTPM
classical monocyte: 14 nTPM
T-reg: 13 nTPM

Brain region

white matter: 18 nTPM
medulla oblongata: 14 nTPM
choroid plexus: 14 nTPM
hypothalamus: 14 nTPM
cerebellum: 13 nTPM
pons: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Metallo-beta-lactamase
Winged helix-like DNA-binding domain superfamily
Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Metallo-beta-lactamase superfamily
LACTB2, winged helix domain
LACTB2-like, MBL-fold metallo hydrolase domain
Secondary metabolite biosynthesis-associated thioesterase
Beta-lactamase associated winged helix domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LACTB2 as an antibody target. Whether an autoantibody or antibody against LACTB2 could matter depends on whether native LACTB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LACTB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LACTB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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