Seroatlas · Human Serome Atlas

FOXI2

Forkhead box protein I2

Also known as: FLJ46831, FOXI2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZQN5
Gene: FOXI2
Ensembl: ENSG00000186766
Chromosome: 10
Canonical length: 318 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q6ZQN5|FOXI2
     1  MATYCDDLGP SSAPPGQAQA TAHPPGYEPG DLGAVGGGPL LWVNAPALSP KSYASGPGPA
    61  PPYAAPSYGA PGPLLGAPGG LAGADLAWLS LSGQQELLRL VRPPYSYSAL IAMAIQSAPL
   121  RKLTLSQIYQ YVAGNFPFYK RSKAGWQNSI RHNLSLNDCF KKVPRDEDDP GKGNYWTLDP
   181  NCEKMFDNGN FRRKRKRRAE ASAAVRSGAR SVGGAEAPAL EPPSAACLDL QASPSPSAPE
   241  AATCFSGFAS AMSALAGGLG TFPGGLAGDF SFGRRPPTVA THAPQTLNPS PGFAPGHQTA
   301  AAGFRLSHLL YSREGTEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 2.8 nTPM

Expression across tissuesHPA

Tissue

kidney: 2.8 nTPM
esophagus: 1.8 nTPM
cervix: 1.6 nTPM
pituitary gland: 1.1 nTPM
parathyroid gland: 0.8 nTPM
salivary gland: 0.8 nTPM

Single-cell type

salivary ionocytes: 22 nCPM
epididymal clear cells: 20 nCPM
respiratory ionocytes: 18 nCPM
esophageal apical cells: 5.8 nCPM
thymic myoid cells: 4.1 nCPM
renal collecting duct intercalated cells: 3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.8 nTPM
medulla oblongata: 0.5 nTPM
spinal cord: 0.4 nTPM
cerebellum: 0.3 nTPM
cerebral cortex: 0.3 nTPM
choroid plexus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: -0.09
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOXI2 as an antibody target. Whether an autoantibody or antibody against FOXI2 could matter depends on whether native FOXI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOXI2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOXI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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