Seroatlas · Human Serome Atlas

PA2G4

Proliferation-associated protein 2G4

Also known as: EBP1, PA2G4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UQ80
Gene
PA2G4
Ensembl
ENSG00000170515
Chromosome
12
Canonical length
394 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

394 residues, UniProt reviewed canonical sequence.

>Q9UQ80|PA2G4
     1  MSGEDEQQEQ TIAEDLVVTK YKMGGDIANR VLRSLVEASS SGVSVLSLCE KGDAMIMEET
    61  GKIFKKEKEM KKGIAFPTSI SVNNCVCHFS PLKSDQDYIL KEGDLVKIDL GVHVDGFIAN
   121  VAHTFVVDVA QGTQVTGRKA DVIKAAHLCA EAALRLVKPG NQNTQVTEAW NKVAHSFNCT
   181  PIEGMLSHQL KQHVIDGEKT IIQNPTDQQK KDHEKAEFEV HEVYAVDVLV SSGEGKAKDA
   241  GQRTTIYKRD PSKQYGLKMK TSRAFFSEVE RRFDAMPFTL RAFEDEKKAR MGVVECAKHE
   301  LLQPFNVLYE KEGEFVAQFK FTVLLMPNGP MRITSGPFEP DLYKSEMEVQ DAELKALLQS
   361  SASRKTQKKK KKKASKTAEN ATSGETLEEN EAGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PA2G4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
143 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 143 nTPM
  • esophagus: 133 nTPM
  • bone marrow: 125 nTPM
  • thymus: 115 nTPM
  • tonsil: 113 nTPM
  • skin: 108 nTPM

Single-cell type

  • late primary spermatocytes: 603 nCPM
  • esophageal basal cells: 473 nCPM
  • erythrocyte progenitors: 405 nCPM
  • esophageal suprabasal cells: 350 nCPM
  • migrating cytotrophoblasts: 349 nCPM
  • suprabasal keratinocytes: 320 nCPM

Immune cell

  • MAIT T-cell: 175 nTPM
  • T-reg: 171 nTPM
  • total PBMC: 156 nTPM
  • NK-cell: 152 nTPM
  • memory CD8 T-cell: 141 nTPM
  • memory CD4 T-cell: 137 nTPM

Brain region

  • white matter: 68 nTPM
  • cerebral cortex: 63 nTPM
  • hypothalamus: 59 nTPM
  • medulla oblongata: 58 nTPM
  • cerebellum: 57 nTPM
  • spinal cord: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
1
gnomAD missense Z
3.52
DepMap mean gene effect
-0.52
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PA2G4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PA2G4 as an antibody target. Whether an autoantibody or antibody against PA2G4 could matter depends on whether native PA2G4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PA2G4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PA2G4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PA2G4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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