Seroatlas · Human Serome Atlas

SETMAR

Histone-lysine N-methyltransferase SETMAR

Also known as: metnase, SETMR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q53H47
Gene
SETMAR
Ensembl
ENSG00000170364
Chromosome
3
Canonical length
684 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoli
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

684 residues, UniProt reviewed canonical sequence.

>Q53H47|SETMAR
     1  MFAEAAKTTR PCGMAEFKEK PEAPTEQLDV ACGQENLPVG AWPPGAAPAP FQYTPDHVVG
    61  PGADIDPTQI TFPGCICVKT PCLPGTCSCL RHGENYDDNS CLRDIGSGGK YAEPVFECNV
   121  LCRCSDHCRN RVVQKGLQFH FQVFKTHKKG WGLRTLEFIP KGRFVCEYAG EVLGFSEVQR
   181  RIHLQTKSDS NYIIAIREHV YNGQVMETFV DPTYIGNIGR FLNHSCEPNL LMIPVRIDSM
   241  VPKLALFAAK DIVPEEELSY DYSGRYLNLT VSEDKERLDH GKLRKPCYCG AKSCTAFLPF
   301  DSSLYCPVEK SNISCGNEKE PSMCGSAPSV FPSCKRLTLE TMKMMLDKKQ IRAIFLFEFK
   361  MGRKAAETTR NINNAFGPGT ANERTVQWWF KKFCKGDESL EDEERSGRPS EVDNDQLRAI
   421  IEADPLTTTR EVAEELNVNH STVVRHLKQI GKVKKLDKWV PHELTENQKN RRFEVSSSLI
   481  LRNHNEPFLD RIVTCDEKWI LYDNRRRSAQ WLDQEEAPKH FPKPILHPKK VMVTIWWSAA
   541  GLIHYSFLNP GETITSEKYA QEIDEMNQKL QRLQLALVNR KGPILLHDNA RPHVAQPTLQ
   601  KLNELGYEVL PHPPYSPDLL PTNYHVFKHL NNFLQGKRFH NQQDAENAFQ EFVESQSTDF
   661  YATGINQLIS RWQKCVDCNG SYFD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SETMAR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 13 nTPM
  • endometrium: 12 nTPM
  • smooth muscle: 11 nTPM
  • blood vessel: 9.6 nTPM
  • breast: 9.5 nTPM
  • fallopian tube: 9.5 nTPM

Single-cell type

  • epicardial cells: 43 nCPM
  • adipocytes: 36 nCPM
  • sertoli cells: 35 nCPM
  • cytotrophoblasts: 34 nCPM
  • cardiomyocytes: 30 nCPM
  • breast myoepithelial cells: 28 nCPM

Immune cell

  • naive CD8 T-cell: 1.8 nTPM
  • naive CD4 T-cell: 1.6 nTPM
  • naive B-cell: 1.3 nTPM
  • intermediate monocyte: 1 nTPM
  • memory B-cell: 1 nTPM
  • memory CD4 T-cell: 1 nTPM

Brain region

  • white matter: 15 nTPM
  • basal ganglia: 12 nTPM
  • thalamus: 12 nTPM
  • pons: 11 nTPM
  • medulla oblongata: 11 nTPM
  • cerebellum: 9.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
gnomAD missense Z
0.26
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SETMAR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SETMAR as an antibody target. Whether an autoantibody or antibody against SETMAR could matter depends on whether native SETMAR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SETMAR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SETMAR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SETMAR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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