ETV5

Protein identityUniProt · HPA

UniProt accession

P41161

Gene

ETV5

Ensembl

ENSG00000244405

Chromosome

3

Canonical length

510 aa

Protein class

Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cellular response to oxidative stress; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

510 residues, UniProt reviewed canonical sequence.

>P41161|ETV5
     1  MDGFYDQQVP FMVPGKSRSE ECRGRPVIDR KRKFLDTDLA HDSEELFQDL SQLQEAWLAE
    61  AQVPDDEQFV PDFQSDNLVL HAPPPTKIKR ELHSPSSELS SCSHEQALGA NYGEKCLYNY
   121  CAYDRKPPSG FKPLTPPTTP LSPTHQNPLF PPPQATLPTS GHAPAAGPVQ GVGPAPAPHS
   181  LPEPGPQQQT FAVPRPPHQP LQMPKMMPEN QYPSEQRFQR QLSEPCHPFP PQPGVPGDNR
   241  PSYHRQMSEP IVPAAPPPPQ GFKQEYHDPL YEHGVPGMPG PPAHGFQSPM GIKQEPRDYC
   301  VDSEVPNCQS SYMRGGYFSS SHEGFSYEKD PRLYFDDTCV VPERLEGKVK QEPTMYREGP
   361  PYQRRGSLQL WQFLVTLLDD PANAHFIAWT GRGMEFKLIE PEEVARRWGI QKNRPAMNYD
   421  KLSRSLRYYY EKGIMQKVAG ERYVYKFVCD PDALFSMAFP DNQRPFLKAE SECHLSEEDT
   481  LPLTHFEDSP AYLLDMDRCS SLPYAEGFAY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ETV5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.64

Highest tissue expression

40 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ETV5.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 86 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Myoepithelial tumor

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.09

gnomAD pLI

1

gnomAD missense Z

1.99

DepMap mean gene effect

0.13

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell differentiation
• cellular response to oxidative stress
• locomotory behavior
• male germ-line stem cell asymmetric division
• negative regulation of transcription by RNA polymerase II
• neuromuscular synaptic transmission
• positive regulation of glial cell proliferation
• positive regulation of neuron differentiation
• positive regulation of transcription by RNA polymerase II
• regulation of branching involved in mammary gland duct morphogenesis
• regulation of synapse organization
• regulation of transcription by RNA polymerase II
• skeletal muscle acetylcholine-gated channel clustering

Molecular functions

• DNA binding
• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding
• transcription cis-regulatory region binding

Cellular components

• chromatin
• nucleoplasm
• nucleus
• plasma membrane
• synapse

Protein domainsUniProt · Pfam · InterPro

• Ets domain
• PEA3-type ETS-domain transcription factor, N-terminal
• Winged helix-like DNA-binding domain superfamily
• Winged helix DNA-binding domain superfamily
• ETS family
• Ets-domain
• PEA3 subfamily ETS-domain transcription factor N terminal domain

KeywordsUniProt

• DNA-binding
• Isopeptide bond
• Nucleus
• Phosphoprotein
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of ETV5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• COP1