Seroatlas · Human Serome Atlas

KAT5

Histone acetyltransferase KAT5

Also known as: cPLA2, ESA1, HTATIP, HTATIP1, KAT5_HUMAN, PLIP, TIP60, ZC2HC5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92993
Gene
KAT5
Ensembl
ENSG00000172977
Chromosome
11
Canonical length
513 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

513 residues, UniProt reviewed canonical sequence.

>Q92993|KAT5
     1  MAEVGEIIEG CRLPVLRRNQ DNEDEWPLAE ILSVKDISGR KLFYVHYIDF NKRLDEWVTH
    61  ERLDLKKIQF PKKEAKTPTK NGLPGSRPGS PEREVPASAQ ASGKTLPIPV QITLRFNLPK
   121  EREAIPGGEP DQPLSSSSCL QPNHRSTKRK VEVVSPATPV PSETAPASVF PQNGAARRAV
   181  AAQPGRKRKS NCLGTDEDSQ DSSDGIPSAP RMTGSLVSDR SHDDIVTRMK NIECIELGRH
   241  RLKPWYFSPY PQELTTLPVL YLCEFCLKYG RSLKCLQRHL TKCDLRHPPG NEIYRKGTIS
   301  FFEIDGRKNK SYSQNLCLLA KCFLDHKTLY YDTDPFLFYV MTEYDCKGFH IVGYFSKEKE
   361  STEDYNVACI LTLPPYQRRG YGKLLIEFSY ELSKVEGKTG TPEKPLSDLG LLSYRSYWSQ
   421  TILEILMGLK SESGERPQIT INEISEITSI KKEDVISTLQ YLNLINYYKG QYILTLSEDI
   481  VDGHERAMLK RLLRIDSKCL HFTPKDWSKR GKW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KAT5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
50 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 50 nTPM
  • blood vessel: 46 nTPM
  • skin: 44 nTPM
  • endometrium: 44 nTPM
  • testis: 44 nTPM
  • parathyroid gland: 43 nTPM

Single-cell type

  • syncytiotrophoblasts: 153 nCPM
  • late primary spermatocytes: 99 nCPM
  • esophageal apical cells: 80 nCPM
  • cytotrophoblasts: 67 nCPM
  • extravillous trophoblasts: 66 nCPM
  • migrating cytotrophoblasts: 65 nCPM

Immune cell

  • eosinophil: 59 nTPM
  • basophil: 43 nTPM
  • naive CD4 T-cell: 37 nTPM
  • total PBMC: 36 nTPM
  • NK-cell: 36 nTPM
  • neutrophil: 35 nTPM

Brain region

  • white matter: 41 nTPM
  • cerebellum: 38 nTPM
  • pons: 37 nTPM
  • basal ganglia: 36 nTPM
  • medulla oblongata: 35 nTPM
  • spinal cord: 35 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KAT5.

Disease | AllUniProt

Conditions KAT5 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities (NEDFASB) MIM:619103

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 116 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.09
gnomAD missense Z
3.61
DepMap mean gene effect
-0.64
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KAT5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KAT5 as an antibody target. Whether an autoantibody or antibody against KAT5 could matter depends on whether native KAT5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KAT5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KAT5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KAT5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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