Seroatlas · Human Serome Atlas

CUL3

Cullin-3

Also known as: CUL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13618
Gene
CUL3
Ensembl
ENSG00000036257
Chromosome
2
Canonical length
768 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

768 residues, UniProt reviewed canonical sequence.

>Q13618|CUL3
     1  MSNLSKGTGS RKDTKMRIRA FPMTMDEKYV NSIWDLLKNA IQEIQRKNNS GLSFEELYRN
    61  AYTMVLHKHG EKLYTGLREV VTEHLINKVR EDVLNSLNNN FLQTLNQAWN DHQTAMVMIR
   121  DILMYMDRVY VQQNNVENVY NLGLIIFRDQ VVRYGCIRDH LRQTLLDMIA RERKGEVVDR
   181  GAIRNACQML MILGLEGRSV YEEDFEAPFL EMSAEFFQME SQKFLAENSA SVYIKKVEAR
   241  INEEIERVMH CLDKSTEEPI VKVVERELIS KHMKTIVEME NSGLVHMLKN GKTEDLGCMY
   301  KLFSRVPNGL KTMCECMSSY LREQGKALVS EEGEGKNPVD YIQGLLDLKS RFDRFLLESF
   361  NNDRLFKQTI AGDFEYFLNL NSRSPEYLSL FIDDKLKKGV KGLTEQEVET ILDKAMVLFR
   421  FMQEKDVFER YYKQHLARRL LTNKSVSDDS EKNMISKLKT ECGCQFTSKL EGMFRDMSIS
   481  NTTMDEFRQH LQATGVSLGG VDLTVRVLTT GYWPTQSATP KCNIPPAPRH AFEIFRRFYL
   541  AKHSGRQLTL QHHMGSADLN ATFYGPVKKE DGSEVGVGGA QVTGSNTRKH ILQVSTFQMT
   601  ILMLFNNREK YTFEEIQQET DIPERELVRA LQSLACGKPT QRVLTKEPKS KEIENGHIFT
   661  VNDQFTSKLH RVKIQTVAAK QGESDPERKE TRQKVDDDRK HEIEAAIVRI MKSRKKMQHN
   721  VLVAEVTQQL KARFLPSPVV IKKRIEGLIE REYLARTPED RKVYTYVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CUL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
193 nTPM

Expression across tissuesHPA

Tissue

  • testis: 193 nTPM
  • skeletal muscle: 91 nTPM
  • tongue: 72 nTPM
  • tonsil: 64 nTPM
  • parathyroid gland: 50 nTPM
  • lymph node: 48 nTPM

Single-cell type

  • neutrophils: 729 nCPM
  • late spermatids: 532 nCPM
  • neutrophil progenitors: 395 nCPM
  • innate lymphoid cells: 390 nCPM
  • esophageal apical cells: 372 nCPM
  • b-cells: 362 nCPM

Immune cell

  • NK-cell: 7.1 nTPM
  • eosinophil: 5.7 nTPM
  • basophil: 5.4 nTPM
  • T-reg: 5.2 nTPM
  • neutrophil: 5 nTPM
  • naive B-cell: 4.6 nTPM

Brain region

  • choroid plexus: 43 nTPM
  • white matter: 43 nTPM
  • hypothalamus: 43 nTPM
  • cerebellum: 42 nTPM
  • cerebral cortex: 39 nTPM
  • basal ganglia: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CUL3.

Disease | AllUniProt

Conditions CUL3 is implicated in, by any mechanism.

  • Pseudohypoaldosteronism 2E (PHA2E) MIM:614496
  • Neurodevelopmental disorder with or without autism or seizures (NEDAUS) MIM:619239

Disease | GeneticClinVar

118 pathogenic / likely-pathogenic of 685 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
1
gnomAD missense Z
4.75
DepMap mean gene effect
-0.72
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CUL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CUL3 as an antibody target. Whether an autoantibody or antibody against CUL3 could matter depends on whether native CUL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CUL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CUL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CUL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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