Seroatlas · Human Serome Atlas

NSMCE1

Non-structural maintenance of chromosomes element 1 homolog

Also known as: NSE1, NSE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WV22
Gene: NSMCE1
Ensembl: ENSG00000169189
Chromosome: 16
Canonical length: 266 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Enables protein dimerization activity and ubiquitin protein ligase activity. Involved in DNA damage response. Located in nucleoplasm. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

266 residues, UniProt reviewed canonical sequence.

>Q8WV22|NSMCE1
     1  MQGSTRRMGV MTDVHRRFLQ LLMTHGVLEE WDVKRLQTHC YKVHDRNATV DKLEDFINNI
    61  NSVLESLYIE IKRGVTEDDG RPIYALVNLA TTSISKMATD FAENELDLFR KALELIIDSE
   121  TGFASSTNIL NLVDQLKGKK MRKKEAEQVL QKFVQNKWLI EKEGEFTLHG RAILEMEQYI
   181  RETYPDAVKI CNICHSLLIQ GQSCETCGIR MHLPCVAKYF QSNAEPRCPH CNDYWPHEIP
   241  KVFDPEKERE SGVLKSNKKS LRSRQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NSMCE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 111 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 111 nTPM
parathyroid gland: 81 nTPM
testis: 78 nTPM
adrenal gland: 67 nTPM
kidney: 67 nTPM
blood vessel: 63 nTPM

Single-cell type

late spermatids: 586 nCPM
late primary spermatocytes: 275 nCPM
mast cells: 241 nCPM
early spermatids: 194 nCPM
cytotrophoblasts: 162 nCPM
decidual stromal cells: 151 nCPM

Immune cell

NK-cell: 215 nTPM
naive B-cell: 134 nTPM
myeloid DC: 129 nTPM
naive CD4 T-cell: 127 nTPM
basophil: 126 nTPM
plasmacytoid DC: 125 nTPM

Brain region

white matter: 46 nTPM
choroid plexus: 45 nTPM
medulla oblongata: 44 nTPM
cerebellum: 43 nTPM
spinal cord: 40 nTPM
hypothalamus: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.56
DepMap mean gene effect: -0.44
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, RING-type
Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Zinc finger, RING/FYVE/PHD-type
Winged helix-like DNA-binding domain superfamily
Non-structural maintenance of chromosomes element 1
Non-structural maintenance of chromosomes element 1, RING C4HC3-type
Nse1 non-SMC component of SMC5-6 complex
RING-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NSMCE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NSMCE1 as an antibody target. Whether an autoantibody or antibody against NSMCE1 could matter depends on whether native NSMCE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NSMCE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NSMCE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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