Seroatlas · Human Serome Atlas

VPS36

Vacuolar protein-sorting-associated protein 36

Also known as: C13orf9, CGI-145, Eap45, VPS36_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86VN1
Gene
VPS36
Ensembl
ENSG00000136100
Chromosome
13
Canonical length
386 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Lysosomes,Plasma membrane,Cell Junctions

OverviewNCBI Gene

This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

386 residues, UniProt reviewed canonical sequence.

>Q86VN1|VPS36
     1  MDRFVWTSGL LEINETLVIQ QRGVRIYDGE EKIKFDAGTL LLSTHRLIWR DQKNHECCMA
    61  ILLSQIVFIE EQAAGIGKSA KIVVHLHPAP PNKEPGPFQS SKNSYIKLSF KEHGQIEFYR
   121  RLSEEMTQRR WENMPVSQSL QTNRGPQPGR IRAVGIVGIE RKLEEKRKET DKNISEAFED
   181  LSKLMIKAKE MVELSKSIAN KIKDKQGDIT EDETIRFKSY LLSMGIANPV TRETYGSGTQ
   241  YHMQLAKQLA GILQVPLEER GGIMSLTEVY CLVNRARGME LLSPEDLVNA CKMLEALKLP
   301  LRLRVFDSGV MVIELQSHKE EEMVASALET VSEKGSLTSE EFAKLVGMSV LLAKERLLLA
   361  EKMGHLCRDD SVEGLRFYPN LFMTQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VPS36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • skin: 48 nTPM
  • retina: 40 nTPM
  • cerebellum: 27 nTPM
  • small intestine: 26 nTPM
  • duodenum: 26 nTPM
  • rectum: 26 nTPM

Single-cell type

  • rod photoreceptor cells: 254 nCPM
  • retinal bipolar cells: 136 nCPM
  • myonuclei: 127 nCPM
  • breast myoepithelial cells: 103 nCPM
  • cone photoreceptor cells: 97 nCPM
  • fibro-adipogenic progenitors: 96 nCPM

Immune cell

  • non-classical monocyte: 23 nTPM
  • NK-cell: 22 nTPM
  • MAIT T-cell: 20 nTPM
  • intermediate monocyte: 16 nTPM
  • plasmacytoid DC: 16 nTPM
  • T-reg: 16 nTPM

Brain region

  • cerebral cortex: 32 nTPM
  • cerebellum: 27 nTPM
  • pons: 25 nTPM
  • thalamus: 24 nTPM
  • medulla oblongata: 23 nTPM
  • white matter: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.05
gnomAD missense Z
1.71
DepMap mean gene effect
-0.39
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VPS36 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VPS36 as an antibody target. Whether an autoantibody or antibody against VPS36 could matter depends on whether native VPS36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VPS36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VPS36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VPS36. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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