Seroatlas · Human Serome Atlas

ZBP1

Z-DNA-binding protein 1

Also known as: C20orf183, DAI, dJ718J7.3, DLM-1, DLM1, ZBP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H171
Gene: ZBP1
Ensembl: ENSG00000124256
Chromosome: 20
Canonical length: 429 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

429 residues, UniProt reviewed canonical sequence.

>Q9H171|ZBP1
     1  MAQAPADPGR EGHLEQRILQ VLTEAGSPVK LAQLVKECQA PKRELNQVLY RMKKELKVSL
    61  TSPATWCLGG TDPEGEGPAE LALSSPAERP QQHAATIPET PGPQFSQQRE EDIYRFLKDN
   121  GPQRALVIAQ ALGMRTAKDV NRDLYRMKSR HLLDMDEQSK AWTIYRPEDS GRRAKSASII
   181  YQHNPINMIC QNGPNSWISI ANSEAIQIGH GNIITRQTVS REDGSAGPRH LPSMAPGDSS
   241  TWGTLVDPWG PQDIHMEQSI LRRVQLGHSN EMRLHGVPSE GPAHIPPGSP PVSATAAGPE
   301  ASFEARIPSP GTHPEGEAAQ RIHMKSCFLE DATIGNSNKM SISPGVAGPG GVAGSGEGEP
   361  GEDAGRRPAD TQSRSHFPRD IGQPITPSHS KLTPKLETMT LGNRSHKAAE GSHYVDEASH
   421  EGSWWGGGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 27 nTPM
tonsil: 24 nTPM
lymph node: 22 nTPM
spleen: 21 nTPM
appendix: 18 nTPM
duodenum: 12 nTPM

Single-cell type

plasma cells: 181 nCPM
nk-cells: 46 nCPM
t-cells: 33 nCPM
b-cells: 24 nCPM
neutrophils: 20 nCPM
epididymal efferent duct ciliated cells: 14 nCPM

Immune cell

neutrophil: 38 nTPM
NK-cell: 20 nTPM
gdT-cell: 19 nTPM
T-reg: 18 nTPM
eosinophil: 18 nTPM
memory B-cell: 16 nTPM

Brain region

cerebellum: 42 nTPM
cerebral cortex: 38 nTPM
white matter: 37 nTPM
medulla oblongata: 33 nTPM
amygdala: 32 nTPM
pons: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: -0.37
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA binding
double-stranded RNA adenosine deaminase activity
double-stranded RNA binding
identical protein binding
RNA binding
left-handed Z-DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBP1 as an antibody target. Whether an autoantibody or antibody against ZBP1 could matter depends on whether native ZBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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