Seroatlas · Human Serome Atlas

LARP1

La-related protein 1

Also known as: KIAA0731, Lar1, LARP, LARP1_HUMAN, Lhp1, MGC19556

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PKG0
Gene: LARP1
Ensembl: ENSG00000155506
Chromosome: 5
Canonical length: 1096 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Enables several functions, including RNA binding activity; eukaryotic initiation factor 4E binding activity; and ribosomal small subunit binding activity. Involved in several processes, including TORC1 signaling; cellular response to rapamycin; and post-transcriptional regulation of gene expression. Located in TORC1 complex and cytoplasmic stress granule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1096 residues, UniProt reviewed canonical sequence.

>Q6PKG0|LARP1
     1  MATQVEPLLP GGATLLQAEE HGGLVRKKPP PAPEGKGEPG PNDVRGGEPD GSARRPRPPC
    61  AKPHKEGTGQ QERESPRPLQ LPGAEGPAIS DGEEGGGEPG AGGGAAGAAG AGRRDFVEAP
   121  PPKVNPWTKN ALPPVLTTVN GQSPPEHSAP AKVVRAAVPK QRKGSKVGDF GDAINWPTPG
   181  EIAHKSVQPQ SHKPQPTRKL PPKKDMKEQE KGEGSDSKES PKTKSDESGE EKNGDEDCQR
   241  GGQKKKGNKH KWVPLQIDMK PEVPREKLAS RPTRPPEPRH IPANRGEIKG SESATYVPVA
   301  PPTPAWQPEI KPEPAWHDQD ETSSVKSDGA GGARASFRGR GRGRGRGRGR GRGGTRTHFD
   361  YQFGYRKFDG VEGPRTPKYM NNITYYFDNV SSTELYSVDQ ELLKDYIKRQ IEYYFSVDNL
   421  ERDFFLRRKM DADGFLPITL IASFHRVQAL TTDISLIFAA LKDSKVVEIV DEKVRRREEP
   481  EKWPLPPIVD YSQTDFSQLL NCPEFVPRQH YQKETESAPG SPRAVTPVPT KTEEVSNLKT
   541  LPKGLSASLP DLDSENWIEV KKRPRPSPAR PKKSEESRFS HLTSLPQQLP SQQLMSKDQD
   601  EQEELDFLFD EEMEQMDGRK NTFTAWSDEE SDYEIDDRDV NKILIVTQTP HYMRRHPGGD
   661  RTGNHTSRAK MSAELAKVIN DGLFYYEQDL WAEKFEPEYS QIKQEVENFK KVNMISREQF
   721  DTLTPEPPVD PNQEVPPGPP RFQQVPTDAL ANKLFGAPEP STIARSLPTT VPESPNYRNT
   781  RTPRTPRTPQ LKDSSQTSRF YPVVKEGRTL DAKMPRKRKT RHSSNPPLES HVGWVMDSRE
   841  HRPRTASISS SPSEGTPTVG SYGCTPQSLP KFQHPSHELL KENGFTQHVY HKYRRRCLNE
   901  RKRLGIGQSQ EMNTLFRFWS FFLRDHFNKK MYEEFKQLAL EDAKEGYRYG LECLFRYYSY
   961  GLEKKFRLDI FKDFQEETVK DYEAGQLYGL EKFWAFLKYS KAKNLDIDPK LQEYLGKFRR
  1021  LEDFRVDPPM GEEGNHKRHS VVAGGGGGEG RKRCPSQSSS RPAAMISQPP TPPTGQPVRE
  1081  DAKWTSQHSN TQTLGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LARP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

pancreas: 100 nTPM
parathyroid gland: 69 nTPM
skeletal muscle: 66 nTPM
salivary gland: 55 nTPM
thyroid gland: 52 nTPM
heart muscle: 47 nTPM

Single-cell type

myonuclei: 438 nCPM
choroid plexus epithelial cells: 305 nCPM
adrenal medulla cells: 298 nCPM
adipocytes: 290 nCPM
lacrimal acinar cells: 281 nCPM
adrenal cortex cells: 278 nCPM

Immune cell

NK-cell: 5.8 nTPM
non-classical monocyte: 5.5 nTPM
plasmacytoid DC: 3.5 nTPM
MAIT T-cell: 3.2 nTPM
intermediate monocyte: 2.9 nTPM
memory CD8 T-cell: 2.9 nTPM

Brain region

pons: 217 nTPM
cerebral cortex: 210 nTPM
midbrain: 204 nTPM
white matter: 182 nTPM
hippocampal formation: 181 nTPM
amygdala: 173 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LARP1.

Disease | ImmuneIEDB

Conditions an epitope on LARP1 was assayed in.

chronic myeloid leukemia T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 3.07
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LARP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LARP1 as an antibody target. Whether an autoantibody or antibody against LARP1 could matter depends on whether native LARP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LARP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LARP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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