Seroatlas · Human Serome Atlas

DEPTOR

DEP domain-containing mTOR-interacting protein

Also known as: DEP.6, DEPDC6, DPTOR_HUMAN, FLJ12428

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TB45
Gene: DEPTOR
Ensembl: ENSG00000155792
Chromosome: 8
Canonical length: 409 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Mitochondria

OverviewNCBI Gene

Enables phosphatidic acid binding activity and protein serine/threonine kinase inhibitor activity. Involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

409 residues, UniProt reviewed canonical sequence.

>Q8TB45|DEPTOR
     1  MEEGGSTGSA GSDSSTSGSG GAQQRELERM AEVLVTGEQL RLRLHEEKVI KDRRHHLKTY
    61  PNCFVAKELI DWLIEHKEAS DRETAIKLMQ KLADRGIIHH VCDEHKEFKD VKLFYRFRKD
   121  DGTFPLDNEV KAFMRGQRLY EKLMSPENTL LQPREEEGVK YERTFMASEF LDWLVQEGEA
   181  TTRKEAEQLC HRLMEHGIIQ HVSNKHPFVD SNLLYQFRMN FRRRRRLMEL LNEKSPSSQE
   241  THDSPFCLRK QSHDNRKSTS FMSVSPSKEI KIVSAVRRSS MSSCGSSGYF SSSPTLSSSP
   301  PVLCNPKSVL KRPVTSEELL TPGAPYARKT FTIVGDAVGW GFVVRGSKPC HIQAVDPSGP
   361  AAAAGMKVCQ FVVSVNGLNV LHVDYRTVSN LILTGPRTIV MEVMEELEC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DEPTOR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 148 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 148 nTPM
tongue: 114 nTPM
salivary gland: 100 nTPM
thyroid gland: 92 nTPM
adrenal gland: 50 nTPM
stomach: 38 nTPM

Single-cell type

myonuclei: 834 nCPM
loop of henle epithelial cells: 578 nCPM
pituicytes/fscs: 449 nCPM
distal convoluted tubule cells: 417 nCPM
salivary acinar cells: 321 nCPM
lacrimal acinar cells: 319 nCPM

Immune cell

myeloid DC: 20 nTPM
intermediate monocyte: 1.7 nTPM
plasmacytoid DC: 1 nTPM
total PBMC: 1 nTPM
classical monocyte: 0.9 nTPM
naive CD4 T-cell: 0.9 nTPM

Brain region

hypothalamus: 51 nTPM
white matter: 51 nTPM
basal ganglia: 36 nTPM
thalamus: 36 nTPM
medulla oblongata: 35 nTPM
spinal cord: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: 0.09
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

DEP domain
PDZ domain
PDZ superfamily
Winged helix-like DNA-binding domain superfamily
Winged helix DNA-binding domain superfamily
Regulators of mTOR signaling and Rac activation
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
DEP domain-containing mTOR-interacting protein, DEP domain 1
DEP domain-containing mTOR-interacting protein, DEP domain 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DEPTOR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DEPTOR as an antibody target. Whether an autoantibody or antibody against DEPTOR could matter depends on whether native DEPTOR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DEPTOR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DEPTOR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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