Seroatlas · Human Serome Atlas

PLEK2

Pleckstrin-2

Also known as: PLEK2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYT0
Gene: PLEK2
Ensembl: ENSG00000100558
Chromosome: 14
Canonical length: 353 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

353 residues, UniProt reviewed canonical sequence.

>Q9NYT0|PLEK2
     1  MEDGVLKEGF LVKRGHIVHN WKARWFILRQ NTLVYYKLEG GRRVTPPKGR ILLDGCTITC
    61  PCLEYENRPL LIKLKTQTST EYFLEACSRE ERDAWAFEIT GAIHAGQPGK VQQLHSLRNS
   121  FKLPPHISLH RIVDKMHDSN TGIRSSPNME QGSTYKKTFL GSSLVDWLIS NSFTASRLEA
   181  VTLASMLMEE NFLRPVGVRS MGAIRSGDLA EQFLDDSTAL YTFAESYKKK ISPKEEISLS
   241  TVELSGTVVK QGYLAKQGHK RKNWKVRRFV LRKDPAFLHY YDPSKEENRP VGGFSLRGSL
   301  VSALEDNGVP TGVKGNVQGN LFKVITKDDT HYYIQASSKA ERAEWIEAIK KLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 49 nTPM
small intestine: 31 nTPM
epididymis: 31 nTPM
duodenum: 28 nTPM
liver: 28 nTPM
rectum: 27 nTPM

Single-cell type

basal keratinocytes: 125 nCPM
suprabasal keratinocytes: 79 nCPM
esophageal basal cells: 74 nCPM
gastric progenitor cells: 68 nCPM
paneth cells: 62 nCPM
goblet cells: 60 nCPM

Immune cell

naive CD4 T-cell: 3.1 nTPM
memory CD4 T-cell: 2 nTPM
total PBMC: 0.5 nTPM
myeloid DC: 0.4 nTPM
memory CD8 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM

Brain region

cerebellum: 1.8 nTPM
thalamus: 1.2 nTPM
cerebral cortex: 1 nTPM
hippocampal formation: 1 nTPM
white matter: 0.9 nTPM
basal ganglia: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: 0.82
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

actin cytoskeleton organization
intracellular signal transduction
positive regulation of plasma membrane bounded cell projection assembly

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEK2 as an antibody target. Whether an autoantibody or antibody against PLEK2 could matter depends on whether native PLEK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLEK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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