Seroatlas · Human Serome Atlas

FOXD4L3

Forkhead box protein D4-like 3

Also known as: FOXD6, FX4L3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6VB84
Gene: FOXD4L3
Ensembl: ENSG00000187559
Chromosome: 9
Canonical length: 417 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>Q6VB84|FOXD4L3
     1  MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF LEQSLQPGLQ
    61  VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA
   121  ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN
   181  YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PRPGPLLGAP
   241  APPQPVPGAY PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS
   301  PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRICPRPRG ATATCSSDHQ
   361  ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL PPRARCWAGT CRPRRPC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXD4L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 0.8 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 0.8 nTPM
cerebral cortex: 0.6 nTPM
cerebellum: 0.5 nTPM
thymus: 0.5 nTPM
basal ganglia: 0.3 nTPM
amygdala: 0.2 nTPM

Single-cell type

brain excitatory neurons: 0.1 nCPM
brain inhibitory neurons: 0.1 nCPM
breast hormone-responsive cells: 0.1 nCPM
breast secretory cells: 0.1 nCPM
colonocytes: 0.1 nCPM
goblet cells: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 4.2 nTPM
cerebral cortex: 3.3 nTPM
white matter: 1.7 nTPM
amygdala: 1.1 nTPM
pons: 1.1 nTPM
basal ganglia: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0.5
gnomAD missense Z: -1.68

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOXD4L3 as an antibody target. Whether an autoantibody or antibody against FOXD4L3 could matter depends on whether native FOXD4L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOXD4L3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOXD4L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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