Seroatlas · Human Serome Atlas

EIF3C

Eukaryotic translation initiation factor 3 subunit C

Also known as: eIF3-p110, EIF3C_HUMAN, EIF3S8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99613
Gene: EIF3C
Ensembl: ENSG00000184110
Chromosome: 16
Canonical length: 913 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables ribosome binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of translation and translational initiation. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

913 residues, UniProt reviewed canonical sequence.

>Q99613|EIF3C
     1  MSRFFTTGSD SESESSLSGE ELVTKPVGGN YGKQPLLLSE DEEDTKRVVR SAKDKRFEEL
    61  TNLIRTIRNA MKIRDVTKCL EEFELLGKAY GKAKSIVDKE GVPRFYIRIL ADLEDYLNEL
   121  WEDKEGKKKM NKNNAKALST LRQKIRKYNR DFESHITSYK QNPEQSADED AEKNEEDSEG
   181  SSDEDEDEDG VSAATFLKKK SEAPSGESRK FLKKMDDEDE DSEDSEDDED WDTGSTSSDS
   241  DSEEEEGKQT ALASRFLKKA PTTDEDKKAA EKKREDKAKK KHDRKSKRLD EEEEDNEGGE
   301  WERVRGGVPL VKEKPKMFAK GTEITHAVVI KKLNEILQAR GKKGTDRAAQ IELLQLLVQI
   361  AAENNLGEGV IVKIKFNIIA SLYDYNPNLA TYMKPEMWGK CLDCINELMD ILFANPNIFV
   421  GENILEESEN LHNADQPLRV RGCILTLVER MDEEFTKIMQ NTDPHSQEYV EHLKDEAQVC
   481  AIIERVQRYL EEKGTTEEVC RIYLLRILHT YYKFDYKAHQ RQLTPPEGSS KSEQDQAENE
   541  GEDSAVLMER LCKYIYAKDR TDRIRTCAIL CHIYHHALHS RWYQARDLML MSHLQDNIQH
   601  ADPPVQILYN RTMVQLGICA FRQGLTKDAH NALLDIQSSG RAKELLGQGL LLRSLQERNQ
   661  EQEKVERRRQ VPFHLHINLE LLECVYLVSA MLLEIPYMAA HESDARRRMI SKQFHHQLRV
   721  GERQPLLGPP ESMREHVVAA SKAMKMGDWK TCHSFIINEK MNGKVWDLFP EADKVRTMLV
   781  RKIQEESLRT YLFTYSSVYD SISMETLSDM FELDLPTVHS IISKMIINEE LMASLDQPTQ
   841  TVVMHRTEPT AQQNLALQLA EKLGSLVENN ERVFDHKQGT YGGYFRDQKD GYRKNEGYMR
   901  RGGYRQQQSQ TAY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 337 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 337 nTPM
tongue: 272 nTPM
parathyroid gland: 214 nTPM
pancreas: 207 nTPM
ovary: 197 nTPM
skin: 178 nTPM

Single-cell type

other brain neurons: 51 nCPM
brain excitatory neurons: 30 nCPM
brain inhibitory neurons: 29 nCPM
oligodendrocytes: 25 nCPM
ependymal cells: 24 nCPM
oligodendrocyte progenitor cells: 20 nCPM

Immune cell

total PBMC: 267 nTPM
non-classical monocyte: 222 nTPM
myeloid DC: 213 nTPM
intermediate monocyte: 204 nTPM
classical monocyte: 198 nTPM
NK-cell: 164 nTPM

Brain region

hippocampal formation: 176 nTPM
pons: 168 nTPM
cerebral cortex: 168 nTPM
midbrain: 166 nTPM
basal ganglia: 165 nTPM
hypothalamus: 159 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: 0.07

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF3C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF3C as an antibody target. Whether an autoantibody or antibody against EIF3C could matter depends on whether native EIF3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF3C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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