Seroatlas · Human Serome Atlas

ZC3HAV1L

Zinc finger CCCH-type antiviral protein 1-like

Also known as: C7orf39, MGC14289, ZCCHL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96H79
Gene: ZC3HAV1L
Ensembl: ENSG00000146858
Chromosome: 7
Canonical length: 300 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

300 residues, UniProt reviewed canonical sequence.

>Q96H79|ZC3HAV1L
     1  MAEPTVCSFL TKVLCAHGGR MFLKDLRGHV ELSEARLRDV LQRAGPERFL LQEVETQEGL
    61  GDAEAEAAAG AVGGGGTSAW RVVAVSSVRL CARYQRGECQ ACDQLHFCRR HMLGKCPNRD
   121  CWSTCTLSHD IHTPVNMQVL KSHGLFGLNE NQLRILLLQN DPCLLPEVCL LYNKGEALYG
   181  YCNLKDKCNK FHVCKSFVKG ECKLQTCKRS HQLIHAASLK LLQDQGLNIP SVVNFQIIST
   241  YKHMKLHKML ENTDNSSPST EHSQGLEKQG VHAAGAAEAG PLASVPAQSA KKPCPVSCEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3HAV1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 8.9 nTPM

Expression across tissuesHPA

Tissue

placenta: 8.9 nTPM
skin: 8.1 nTPM
thyroid gland: 7.7 nTPM
ovary: 6.7 nTPM
endometrium: 6.3 nTPM
smooth muscle: 4.9 nTPM

Single-cell type

adipocytes: 17 nCPM
gonadotrophs: 11 nCPM
adrenal medulla cells: 11 nCPM
renal collecting duct principal cells: 7.4 nCPM
fibro-adipogenic progenitors: 7.2 nCPM
lactotrophs: 7.2 nCPM

Immune cell

basophil: 10 nTPM
eosinophil: 0.9 nTPM
naive B-cell: 0.9 nTPM
memory B-cell: 0.4 nTPM
neutrophil: 0.4 nTPM
memory CD4 T-cell: 0.3 nTPM

Brain region

choroid plexus: 26 nTPM
hypothalamus: 14 nTPM
hippocampal formation: 12 nTPM
basal ganglia: 11 nTPM
amygdala: 9.4 nTPM
cerebral cortex: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 0.51
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

Winged helix-like DNA-binding domain superfamily
ZAP, helix turn helix N-terminal domain
PARP12-like, CCCH zinc finger tandem
Zap helix turn helix N-terminal domain
PARP12-like CCCH zinc finger tandem
Zinc finger CCCH-type antiviral protein 1-like

KeywordsUniProt

Acetylation

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3HAV1L as an antibody target. Whether an autoantibody or antibody against ZC3HAV1L could matter depends on whether native ZC3HAV1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3HAV1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3HAV1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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