FOXJ2
Forkhead box protein J2
Also known as: FHX, FOXJ2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9P0K8
- Gene
- FOXJ2
- Ensembl
- ENSG00000065970
- Chromosome
- 12
- Canonical length
- 574 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nucleoli fibrillar center
OverviewNCBI Gene
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell differentiation; and positive regulation of vascular associated smooth muscle cell proliferation. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
574 residues, UniProt reviewed canonical sequence.
>Q9P0K8|FOXJ2
1 MASDLESSLT SIDWLPQLTL RATIEKLGSA SQAGPPGSSR KCSPGSPTDP NATLSKDEAA
61 VHQDGKPRYS YATLITYAIN SSPAKKMTLS EIYRWICDNF PYYKNAGIGW KNSIRHNLSL
121 NKCFRKVPRP RDDPGKGSYW TIDTCPDISR KRRHPPDDDL SQDSPEQEAS KSPRGGVAGS
181 GEASLPPEGN PQMSLQSPTS IASYSQGTGS VDGGAVAAGA SGRESAEGPP PLYNTNHDFK
241 FSYSEINFQD LSWSFRNLYK SMLEKSSSSS QHGFSSLLGD IPPSNNYYMY QQQQPPPPQQ
301 QQQQQQPPQP PPQQSQPQQQ QAPAQGPSAV GGAPPLHTPS TDGCTPPGGK QAGAEGYGPP
361 PVMAMHPPPL QHGGYHPHQH HPHSHPAQQP PPPQPQAQGQ APINNTGFAF PSDWCSNIDS
421 LKESFKMVNR LNWSSIEQSQ FSELMESLRQ AEQKNWTLDQ HHIANLCDSL NHFLTQTGHV
481 PPQGGTHRPP APARIADSCA LTSGKQESAM SQVNSYGHPQ APHLYPGPSP MYPIPTQDSA
541 GYNRPAHHMV PRPSVPPPGA NEEIPDDFDW DLITLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FOXJ2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 24 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 24 nTPM
- tongue: 19 nTPM
- blood vessel: 19 nTPM
- cerebellum: 18 nTPM
- endometrium: 17 nTPM
- skin: 17 nTPM
Single-cell type
- platelets: 41 nCPM
- neutrophils: 35 nCPM
- epicardial cells: 32 nCPM
- cardiomyocytes: 27 nCPM
- smooth muscle cells: 25 nCPM
- neutrophil progenitors: 25 nCPM
Immune cell
- NK-cell: 2.9 nTPM
- neutrophil: 2.8 nTPM
- basophil: 2.5 nTPM
- eosinophil: 2.2 nTPM
- MAIT T-cell: 1.9 nTPM
- myeloid DC: 1.8 nTPM
Brain region
- cerebellum: 33 nTPM
- cerebral cortex: 28 nTPM
- white matter: 18 nTPM
- amygdala: 17 nTPM
- hypothalamus: 17 nTPM
- basal ganglia: 17 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.24
- gnomAD pLI
- 1
- gnomAD missense Z
- 0.82
- DepMap mean gene effect
- 0
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cell differentiation
- male meiosis I
- negative regulation of angiogenesis
- positive regulation of DNA-templated transcription
- positive regulation of transcription by RNA polymerase II
- positive regulation of vascular associated smooth muscle cell proliferation
- regulation of transcription by RNA polymerase II
- spermatogenesis
- negative regulation of blood vessel endothelial cell differentiation
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- identical protein binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FOXJ2 as an antibody target. Whether an autoantibody or antibody against FOXJ2 could matter depends on whether native FOXJ2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FOXJ2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FOXJ2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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