Seroatlas · Human Serome Atlas

IRF7

Interferon regulatory factor 7

Also known as: IRF7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92985
Gene
IRF7
Ensembl
ENSG00000185507
Chromosome
11
Canonical length
503 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. The encoded protein plays an important role in the innate immune response against DNA and RNA viruses. [provided by RefSeq, Jul 2021]

Canonical amino-acid sequenceUniProt

503 residues, UniProt reviewed canonical sequence.

>Q92985|IRF7
     1  MALAPERAAP RVLFGEWLLG EISSGCYEGL QWLDEARTCF RVPWKHFARK DLSEADARIF
    61  KAWAVARGRW PPSSRGGGPP PEAETAERAG WKTNFRCALR STRRFVMLRD NSGDPADPHK
   121  VYALSRELCW REGPGTDQTE AEAPAAVPPP QGGPPGPFLA HTHAGLQAPG PLPAPAGDKG
   181  DLLLQAVQQS CLADHLLTAS WGADPVPTKA PGEGQEGLPL TGACAGGPGL PAGELYGWAV
   241  ETTPSPGPQP AALTTGEAAA PESPHQAEPY LSPSPSACTA VQEPSPGALD VTIMYKGRTV
   301  LQKVVGHPSC TFLYGPPDPA VRATDPQQVA FPSPAELPDQ KQLRYTEELL RHVAPGLHLE
   361  LRGPQLWARR MGKCKVYWEV GGPPGSASPS TPACLLPRNC DTPIFDFRVF FQELVEFRAR
   421  QRRGSPRYTI YLGFGQDLSA GRPKEKSLVL VKLEPWLCRV HLEGTQREGV SSLDSSSLSL
   481  CLSSANSLYD DIECFLMELE QPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IRF7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • liver: 39 nTPM
  • spleen: 34 nTPM
  • lung: 15 nTPM
  • small intestine: 15 nTPM
  • esophagus: 13 nTPM
  • kidney: 12 nTPM

Single-cell type

  • pdcs: 790 nCPM
  • esophageal apical cells: 55 nCPM
  • extravillous trophoblasts: 38 nCPM
  • cdc: 33 nCPM
  • late spermatids: 32 nCPM
  • breast lactating cells: 31 nCPM

Immune cell

  • plasmacytoid DC: 598 nTPM
  • non-classical monocyte: 50 nTPM
  • intermediate monocyte: 46 nTPM
  • eosinophil: 31 nTPM
  • myeloid DC: 24 nTPM
  • naive B-cell: 21 nTPM

Brain region

  • medulla oblongata: 3.4 nTPM
  • choroid plexus: 3.3 nTPM
  • pons: 2.9 nTPM
  • cerebral cortex: 1.8 nTPM
  • midbrain: 1.8 nTPM
  • cerebellum: 1.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IRF7.

Disease | AllUniProt

Conditions IRF7 is implicated in, by any mechanism.

  • Immunodeficiency 39, susceptibility to viral infections (IMD39) MIM:616345

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 782 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Immunodeficiency 39

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.57
gnomAD pLI
0
gnomAD missense Z
-0.85
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IRF7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IRF7 as an antibody target. Whether an autoantibody or antibody against IRF7 could matter depends on whether native IRF7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IRF7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IRF7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IRF7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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