Seroatlas · Human Serome Atlas

ELF2

ETS-related transcription factor Elf-2

Also known as: ELF2_HUMAN, EU32, NERF, NERF-1A, NERF-1B, NERF-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15723
Gene: ELF2
Ensembl: ENSG00000109381
Chromosome: 4
Canonical length: 593 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of DNA-templated transcription; positive regulation of DNA-templated transcription; and regulation of transcription by RNA polymerase II. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

593 residues, UniProt reviewed canonical sequence.

>Q15723|ELF2
     1  MTSAVVDSGG TILELSSNGV ENQEESEKVS EYPAVIVEPV PSARLEQGYA AQVLVYDDET
    61  YMMQDVAEEQ EVETENVETV EASVHSSNAH CTDKTIEAAE ALLHMESPTC LRDSRSPVEV
   121  FVPPCVSTPE FIHAAMRPDV ITETVVEVST EESEPMDTSP IPTSPDSHEP MKKKKVGRKP
   181  KTQQSPISNG SPELGIKKKP REGKGNTTYL WEFLLDLLQD KNTCPRYIKW TQREKGIFKL
   241  VDSKAVSKLW GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK DMPKNIVVID
   301  DDKSETCNED LAGTTDEKSL ERVSLSAESL LKAASSVRSG KNSSPINCSR AEKGVARVVN
   361  ITSPGHDASS RSPTTTASVS ATAAPRTVRV AMQVPVVMTS LGQKISTVAV QSVNAGAPLI
   421  TSTSPTTATS PKVVIQTIPT VMPASTENGD KITMQPAKII TIPATQLAQC QLQTKSNLTG
   481  SGSINIVGTP LAVRALTPVS IAHGTPVMRL SMPTQQASGQ TPPRVISAVI KGPEVKSEAV
   541  AKKQEHDVKT LQLVEEKPAD GNKTVTHVVV VSAPSAIALP VTMKTEGLVT CEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 45 nTPM
testis: 35 nTPM
skeletal muscle: 34 nTPM
tongue: 31 nTPM
thymus: 31 nTPM
retina: 28 nTPM

Single-cell type

neutrophils: 4,634 nCPM
myonuclei: 868 nCPM
neutrophil progenitors: 829 nCPM
monocytes: 660 nCPM
retinal ganglion cells: 537 nCPM
salivary basal cells: 526 nCPM

Immune cell

naive B-cell: 20 nTPM
plasmacytoid DC: 18 nTPM
memory B-cell: 18 nTPM
naive CD4 T-cell: 15 nTPM
eosinophil: 14 nTPM
naive CD8 T-cell: 14 nTPM

Brain region

white matter: 40 nTPM
cerebellum: 39 nTPM
basal ganglia: 35 nTPM
medulla oblongata: 33 nTPM
pons: 33 nTPM
hypothalamus: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ELF2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 84 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 0.99
gnomAD missense Z: 1.59
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELF2 as an antibody target. Whether an autoantibody or antibody against ELF2 could matter depends on whether native ELF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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