Seroatlas · Human Serome Atlas

RPS10

Small ribosomal subunit protein eS10

Also known as: MGC88819, RS10_HUMAN, S10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P46783
Gene
RPS10
Ensembl
ENSG00000124614
Chromosome
6
Canonical length
165 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Ribosomal proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring locus NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3).[provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

165 residues, UniProt reviewed canonical sequence.

>P46783|RPS10
     1  MLMPKKNRIA IYELLFKEGV MVAKKDVHMP KHPELADKNV PNLHVMKAMQ SLKSRGYVKE
    61  QFAWRHFYWY LTNEGIQYLR DYLHLPPEIV PATLRRSRPE TGRPRPKGLE GERPARLTRG
   121  EADRDTYRRS AVPPGADKKA EAGAGSATEF QFRGGFGRGR GQPPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
3,208 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 3,208 nTPM
  • pancreas: 2,684 nTPM
  • skin: 2,637 nTPM
  • bone marrow: 2,535 nTPM
  • esophagus: 2,214 nTPM
  • cervix: 2,069 nTPM

Single-cell type

  • gastric progenitor cells: 3,355 nCPM
  • epididymal basal cells: 2,711 nCPM
  • epididymal efferent duct absorptive cells: 2,625 nCPM
  • enteric stem cells: 2,419 nCPM
  • enteric transient amplifying cells: 2,348 nCPM
  • paneth cells: 2,224 nCPM

Immune cell

  • total PBMC: 5,400 nTPM
  • naive CD4 T-cell: 3,096 nTPM
  • memory B-cell: 2,839 nTPM
  • naive B-cell: 2,749 nTPM
  • naive CD8 T-cell: 2,471 nTPM
  • memory CD4 T-cell: 2,416 nTPM

Brain region

  • thalamus: 486 nTPM
  • spinal cord: 478 nTPM
  • white matter: 418 nTPM
  • medulla oblongata: 409 nTPM
  • amygdala: 394 nTPM
  • basal ganglia: 388 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPS10.

Disease | AllUniProt

Conditions RPS10 is implicated in, by any mechanism.

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 159 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

ReferencesPubMed · IEDB

Publications for RPS10 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

2 publications

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
0.97
gnomAD missense Z
1.24
DepMap mean gene effect
-1.31
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS10 as an antibody target. Whether an autoantibody or antibody against RPS10 could matter depends on whether native RPS10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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