Seroatlas · Human Serome Atlas

RGS9

Regulator of G-protein signaling 9

Also known as: MGC111763, MGC26458, PERRS, RGS9_HUMAN, RGS9L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75916
Gene
RGS9
Ensembl
ENSG00000108370
Chromosome
17
Canonical length
674 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

674 residues, UniProt reviewed canonical sequence.

>O75916|RGS9
     1  MTIRHQGQQY RPRMAFLQKI EALVKDMQNP ETGVRMQNQR VLVTSVPHAM TGSDVLQWIV
    61  QRLWISSLEA QNLGNFIVRY GYIYPLQDPK NLILKPDGSL YRFQTPYFWP TQQWPAEDTD
   121  YAIYLAKRNI KKKGILEEYE KENYNFLNQK MNYKWDFVIM QAKEQYRAGK ERNKADRYAL
   181  DCQEKAYWLV HRCPPGMDNV LDYGLDRVTN PNEVKVNQKQ TVVAVKKEIM YYQQALMRST
   241  VKSSVSLGGI VKYSEQFSSN DAIMSGCLPS NPWITDDTQF WDLNAKLVEI PTKMRVERWA
   301  FNFSELIRDP KGRQSFQYFL KKEFSGENLG FWEACEDLKY GDQSKVKEKA EEIYKLFLAP
   361  GARRWINIDG KTMDITVKGL KHPHRYVLDA AQTHIYMLMK KDSYARYLKS PIYKDMLAKA
   421  IEPQETTKKS STLPFMRRHL RSSPSPVILR QLEEEAKARE AANTVDITQP GQHMAPSPHL
   481  TVYTGTCMPP SPSSPFSSSC RSPRKPFASP SRFIRRPSTT ICPSPIRVAL ESSSGLEQKG
   541  ECSGSMAPRG PSVTESSEAS LDTSWPRSRP RAPPKARMAL SFSRFLRRGC LASPVFARLS
   601  PKCPAVSHGR VQPLGDVGQQ LPRLKSKRVA NFFQIKMDVP TGSGTCLMDS EDAGTGESGD
   661  RATEKEVICP WESL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGS9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
63 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 63 nTPM
  • fallopian tube: 15 nTPM
  • pituitary gland: 12 nTPM
  • hypothalamus: 11 nTPM
  • colon: 8.2 nTPM
  • parathyroid gland: 5.2 nTPM

Single-cell type

  • rod photoreceptor cells: 906 nCPM
  • cone photoreceptor cells: 691 nCPM
  • retinal horizontal cells: 162 nCPM
  • pancreatic islet cells: 133 nCPM
  • brain inhibitory neurons: 119 nCPM
  • platelets: 106 nCPM

Immune cell

  • gdT-cell: 9.8 nTPM
  • memory CD8 T-cell: 6.8 nTPM
  • NK-cell: 4 nTPM
  • naive CD8 T-cell: 3.2 nTPM
  • MAIT T-cell: 2.5 nTPM
  • total PBMC: 1.7 nTPM

Brain region

  • basal ganglia: 42 nTPM
  • hypothalamus: 13 nTPM
  • thalamus: 8.6 nTPM
  • pons: 8 nTPM
  • midbrain: 5.4 nTPM
  • medulla oblongata: 4.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RGS9.

Disease | AllUniProt

Conditions RGS9 is implicated in, by any mechanism.

  • Prolonged electroretinal response suppression 1 (PERRS1) MIM:608415

Disease | GeneticClinVar

39 pathogenic / likely-pathogenic of 587 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0
gnomAD missense Z
0.04
DepMap mean gene effect
0.15
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RGS9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGS9 as an antibody target. Whether an autoantibody or antibody against RGS9 could matter depends on whether native RGS9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGS9 is annotated at the cell surface, where native RGS9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RGS9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RGS9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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