ELK1
ETS domain-containing protein Elk-1
Also known as: ELK1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P19419
- Gene
- ELK1
- Ensembl
- ENSG00000126767
- Chromosome
- X
- Canonical length
- 428 aa
- Protein class
- Predicted intracellular proteins, RAS pathway related proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]
Canonical amino-acid sequenceUniProt
428 residues, UniProt reviewed canonical sequence.
>P19419|ELK1
1 MDPSVTLWQF LLQLLREQGN GHIISWTSRD GGEFKLVDAE EVARLWGLRK NKTNMNYDKL
61 SRALRYYYDK NIIRKVSGQK FVYKFVSYPE VAGCSTEDCP PQPEVSVTST MPNVAPAAIH
121 AAPGDTVSGK PGTPKGAGMA GPGGLARSSR NEYMRSGLYS TFTIQSLQPQ PPPHPRPAVV
181 LPSAAPAGAA APPSGSRSTS PSPLEACLEA EEAGLPLQVI LTPPEAPNLK SEELNVEPGL
241 GRALPPEVKV EGPKEELEVA GERGFVPETT KAEPEVPPQE GVPARLPAVV MDTAGQAGGH
301 AASSPEISQP QKGRKPRDLE LPLSPSLLGG PGPERTPGSG SGSGLQAPGP ALTPSLLPTH
361 TLTPVLLTPS SLPPSIHFWS TLSPIAPRSP AKLSFQFPSS GSAQVHIPSI SVDGLSTPVV
421 LSPGPQKPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ELK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 51 nTPM
Expression across tissuesHPA
Tissue
- ovary: 51 nTPM
- basal ganglia: 49 nTPM
- cerebellum: 48 nTPM
- cerebral cortex: 48 nTPM
- amygdala: 42 nTPM
- hippocampal formation: 39 nTPM
Single-cell type
- granulosa cells: 145 nCPM
- breast lactating cells: 46 nCPM
- platelets: 41 nCPM
- adrenal cortex cells: 31 nCPM
- thymic myoid cells: 30 nCPM
- peritubular myoid cells: 30 nCPM
Immune cell
- T-reg: 9.8 nTPM
- myeloid DC: 9.5 nTPM
- intermediate monocyte: 7.2 nTPM
- memory CD4 T-cell: 6.8 nTPM
- non-classical monocyte: 6.6 nTPM
- plasmacytoid DC: 6.5 nTPM
Brain region
- amygdala: 122 nTPM
- cerebral cortex: 103 nTPM
- hippocampal formation: 93 nTPM
- hypothalamus: 83 nTPM
- basal ganglia: 83 nTPM
- white matter: 56 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.34
- gnomAD pLI
- 0.94
- gnomAD missense Z
- 2.19
- DepMap mean gene effect
- -0.18
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cell differentiation
- cellular response to gamma radiation
- cellular response to testosterone stimulus
- gene expression
- hippocampal neuron apoptotic process
- liver development
- lung development
- positive regulation of DNA-templated transcription
- positive regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
- response to ethanol
- response to fibroblast growth factor
- response to light stimulus
Molecular functions
- chromatin binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- mediator complex binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II-specific DNA-binding transcription factor binding
- sequence-specific double-stranded DNA binding
- transcription cis-regulatory region binding
- transcription regulator activator activity
- transcription regulator inhibitor activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ELK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ELK1 as an antibody target. Whether an autoantibody or antibody against ELK1 could matter depends on whether native ELK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ELK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ELK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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