Seroatlas · Human Serome Atlas

FOXD4

Forkhead box protein D4

Also known as: FKHL9, FOXD4_HUMAN, FOXD4a, FREAC5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q12950
Gene
FOXD4
Ensembl
ENSG00000170122
Chromosome
9
Canonical length
439 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. Mutations in this gene are associated with a complex phenotype consisting of dilated cardiomyopathy, obsessive-compulsive disorders, and suicidality. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

439 residues, UniProt reviewed canonical sequence.

>Q12950|FOXD4
     1  MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEEE AASQQFLEQS LQPGLQVARW
    61  GGVALPREHI EGGGGPSDPS EFGTEFRAPP RSAAASEDAR QPAKPPSSYI ALITMAILQS
   121  PHKRLTLSGI CAFISDRFPY YRRKFPAWQN SIRHNLSLND CFVKIPREPG RPGKGNYWSL
   181  DPASQDMFDN GSFLRRRKRF QRHQPTPGAH LPHPFPLPAA HAALHNPRPG PLLGAPAPPQ
   241  PVPGAYPNTG PGRRPYALLH PHPPRYLLLS APAYAGAPKK AEGADLATPA PFPCCSPHLV
   301  LSLGRRARVW RRHREADASL SALRVSCKGS GERVQGLRRV CPRPRGATAP CSSDRQACRT
   361  ILQQQQRHQE EDCANGCAPT KGAVLGGHLS AASALLRYQA VAEGSGLTSL AAPLGGEGTS
   421  PVFLVSPTPS SLAESAGPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
2.7 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 2.7 nTPM
  • testis: 1 nTPM
  • cerebral cortex: 0.8 nTPM
  • hypothalamus: 0.8 nTPM
  • basal ganglia: 0.7 nTPM
  • hippocampal formation: 0.7 nTPM

Single-cell type

  • breast hormone-responsive cells: 0.7 nCPM
  • leydig cells: 0.7 nCPM
  • retinal amacrine cells: 0.7 nCPM
  • brain excitatory neurons: 0.4 nCPM
  • breast secretory cells: 0.4 nCPM
  • lactotrophs: 0.4 nCPM

Immune cell

  • eosinophil: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 2.1 nTPM
  • cerebral cortex: 1.7 nTPM
  • pons: 1.4 nTPM
  • hippocampal formation: 1.3 nTPM
  • thalamus: 1.3 nTPM
  • hypothalamus: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.9
gnomAD pLI
0
gnomAD missense Z
-4.07
DepMap mean gene effect
-0.86
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOXD4 as an antibody target. Whether an autoantibody or antibody against FOXD4 could matter depends on whether native FOXD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOXD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOXD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FOXD4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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