FOXD1

Protein identityUniProt · HPA

UniProt accession

Q16676

Gene

FOXD1

Ensembl

ENSG00000251493

Chromosome

5

Canonical length

465 aa

Protein class

Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Studies of the orthologous mouse protein indicate that it functions in kidney development by promoting nephron progenitor differentiation, and it also functions in the development of the retina and optic chiasm. It may also regulate inflammatory reactions and prevent autoimmunity. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>Q16676|FOXD1
     1  MTLSTEMSDA SGLAEETDID VVGEGEDEED EEEEDDDEGG GGGPRLAVPA QRRRRRRSYA
    61  GEDELEDLEE EEDDDDILLA PPAGGSPAPP GPAPAAGAGA GGGGGGGGAG GGGSAGSGAK
   121  NPLVKPPYSY IALITMAILQ SPKKRLTLSE ICEFISGRFP YYREKFPAWQ NSIRHNLSLN
   181  DCFVKIPREP GNPGKGNYWT LDPESADMFD NGSFLRRRKR FKRQPLLPPN AAAAESLLLR
   241  GAGAAGGAGD PAAAAALFPP APPPPPHAYG YGPYGCGYGL QLPPYAPPSA LFAAAAAAAA
   301  AAAFHPHSPP PPPPPHGAAA ELARTAFGYR PHPLGAALPG PLPASAAKAG GPGASALARS
   361  PFSIESIIGG SLGPAAAAAA AAQAAAAAQA SPSPSPVAAP PAPGSSGGGC AAQAAVGPAA
   421  ALTRSLVAAA AAAASSVSSS AALGTLHQGT ALSSVENFTA RISNC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.66

Highest tissue expression

2.8 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.78

gnomAD pLI

0.69

gnomAD missense Z

0.58

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• anatomical structure morphogenesis
• axon guidance
• canonical Wnt signaling pathway
• cell differentiation
• luteinizing hormone secretion
• metanephric nephron development
• negative regulation of DNA-templated transcription
• positive regulation of BMP signaling pathway
• positive regulation of gene expression
• positive regulation of kidney development
• regulation of transcription by RNA polymerase II
• dichotomous subdivision of terminal units involved in ureteric bud branching
• metanephric capsule development
• metanephric capsule specification
• nephrogenic mesenchyme development

Molecular functions

• DNA binding
• DNA binding, bending
• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific DNA binding

Cellular components

• chromatin
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Fork head domain
• Fork head domain conserved site1
• Fork head domain conserved site 2
• Winged helix-like DNA-binding domain superfamily
• Winged helix DNA-binding domain superfamily
• Forkhead box domain-containing protein
• Forkhead domain

KeywordsUniProt

• DNA-binding
• Nucleus
• Transcription
• Transcription regulation