Seroatlas · Human Serome Atlas

H1-4

Histone H1.4

Also known as: H1.4, H14_HUMAN, H1e, H1F4, H1s-4, HIST1H1E

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P10412
Gene
H1-4
Ensembl
ENSG00000168298
Chromosome
6
Canonical length
219 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>P10412|H1-4
     1  MSETAPAAPA APAPAEKTPV KKKARKSAGA AKRKASGPPV SELITKAVAA SKERSGVSLA
    61  ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG ASGSFKLNKK AASGEAKPKA
   121  KKAGAAKAKK PAGAAKKPKK ATGAATPKKS AKKTPKKAKK PAAAAGAKKA KSPKKAKAAK
   181  PKKAPKSPAK AKAVKPKAAK PKTAKPKAAK PKKAAAKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H1-4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 49 nTPM
  • kidney: 6 nTPM
  • skin: 4.3 nTPM
  • choroid plexus: 3.6 nTPM
  • vagina: 2.9 nTPM
  • breast: 2.8 nTPM

Single-cell type

  • erythrocyte progenitors: 336 nCPM
  • monocyte progenitors: 251 nCPM
  • megakaryocyte progenitors: 203 nCPM
  • plasma cells: 160 nCPM
  • neutrophil progenitors: 131 nCPM
  • nk-cells: 112 nCPM

Immune cell

  • basophil: 258 nTPM
  • naive B-cell: 120 nTPM
  • eosinophil: 107 nTPM
  • MAIT T-cell: 77 nTPM
  • memory B-cell: 74 nTPM
  • NK-cell: 71 nTPM

Brain region

  • cerebellum: 268 nTPM
  • cerebral cortex: 210 nTPM
  • medulla oblongata: 186 nTPM
  • white matter: 175 nTPM
  • spinal cord: 161 nTPM
  • hypothalamus: 157 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H1-4.

Disease | AllUniProt

Conditions H1-4 is implicated in, by any mechanism.

Disease | GeneticClinVar

36 pathogenic / likely-pathogenic of 245 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on H1-4 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.59
gnomAD pLI
0.19
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of H1-4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H1-4 as an antibody target. Whether an autoantibody or antibody against H1-4 could matter depends on whether native H1-4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H1-4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H1-4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H1-4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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