Seroatlas · Human Serome Atlas

HSFX1

Heat shock transcription factor, X-linked

Also known as: HSFX1_HUMAN, HSFX2, LW-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBD0
Gene: HSFX1
Ensembl: ENSG00000171116
Chromosome: X
Canonical length: 423 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>Q9UBD0|HSFX1
     1  MEDKRSLSMA RCEERNSRGQ DHGLERVPFP PQLQSETYLH PADPSPAWDD PGSTGSPNLR
    61  LLTEEIAFQP LAEEASFRRP HPDGDVPPQG EDNLLSLPFP QKLWRLVSSN QFSSIWWDDS
   121  GACRVINQKL FEKEILKRDV AHKVFATTSI KSFFRQLNLY GFRKRRQCTF RTFTRIFSAK
   181  RLVSILNKLE FYCHPYFQRD SPHLLVRMKR RVGVKSAPRH QEEDKPEAAG SCLAPADTEQ
   241  QDHTSPNEND QVTPQHREPA GPNTQIRSGS APPATPVMVP DSAVASDNSP VTQPAGEWSE
   301  GSQAHVTPVA AVPGPAALPF LYVPGSPTQM NSYGPVVALP TASRSTLAMD TTGLPAPGML
   361  PFCHLWVPVT LVAAGAAQPA ASMVMFPHLP ALHHHCPHSH RTSQYMPASD GPQAYPDYAD
   421  QST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSFX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 6 nTPM

Expression across tissuesHPA

Tissue

testis: 6 nTPM
epididymis: 3.1 nTPM
cerebellum: 3 nTPM
ovary: 2.4 nTPM
cerebral cortex: 2 nTPM
spleen: 2 nTPM

Single-cell type

choroid plexus epithelial cells: 0.1 nCPM
distal convoluted tubule cells: 0.1 nCPM
early spermatids: 0.1 nCPM
late primary spermatocytes: 0.1 nCPM
proximal tubule cells: 0.1 nCPM
renal connecting tubule cells: 0.1 nCPM

Immune cell

naive CD8 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 5 nTPM
pons: 4.6 nTPM
hippocampal formation: 4.4 nTPM
cerebral cortex: 4.1 nTPM
cerebellum: 3.2 nTPM
hypothalamus: 3.2 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSFX1 as an antibody target. Whether an autoantibody or antibody against HSFX1 could matter depends on whether native HSFX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSFX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSFX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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