ETS2

Protein identityUniProt · HPA

UniProt accession

P15036

Gene

ETS2

Ensembl

ENSG00000157557

Chromosome

21

Canonical length

469 aa

Protein class

Predicted intracellular proteins, RAS pathway related proteins, Transcription factors

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>P15036|ETS2
     1  MNDFGIKNMD QVAPVANSYR GTLKRQPAFD TFDGSLFAVF PSLNEEQTLQ EVPTGLDSIS
    61  HDSANCELPL LTPCSKAVMS QALKATFSGF KKEQRRLGIP KNPWLWSEQQ VCQWLLWATN
   121  EFSLVNVNLQ RFGMNGQMLC NLGKERFLEL APDFVGDILW EHLEQMIKEN QEKTEDQYEE
   181  NSHLTSVPHW INSNTLGFGT EQAPYGMQTQ NYPKGGLLDS MCPASTPSVL SSEQEFQMFP
   241  KSRLSSVSVT YCSVSQDFPG SNLNLLTNNS GTPKDHDSPE NGADSFESSD SLLQSWNSQS
   301  SLLDVQRVPS FESFEDDCSQ SLCLNKPTMS FKDYIQERSD PVEQGKPVIP AAVLAGFTGS
   361  GPIQLWQFLL ELLSDKSCQS FISWTGDGWE FKLADPDEVA RRWGKRKNKP KMNYEKLSRG
   421  LRYYYDKNII HKTSGKRYVY RFVCDLQNLL GFTPEELHAI LGVQPDTED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ETS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

274 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.2

gnomAD pLI

1

gnomAD missense Z

2.28

DepMap mean gene effect

0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell differentiation
• ectodermal cell fate commitment
• mesoderm development
• negative regulation of transcription by RNA polymerase II
• positive regulation of transcription by RNA polymerase II
• primitive streak formation
• regulation of transcription by RNA polymerase II
• skeletal system development

Molecular functions

• DNA binding
• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• DNA-binding transcription repressor activity, RNA polymerase II-specific
• nuclear glucocorticoid receptor binding
• protein domain specific binding
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• RNA polymerase II-specific DNA-binding transcription factor binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• cytosol
• nucleoplasm
• nucleus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Ets domain
• Pointed domain
• Sterile alpha motif/pointed domain superfamily
• Transforming protein C-ets
• Winged helix-like DNA-binding domain superfamily
• Winged helix DNA-binding domain superfamily
• Ets1, N-terminal flanking region of Ets domain
• ETS family
• Ets-domain
• Sterile alpha motif (SAM)/Pointed domain
• Ets1 N-terminal flanking region of Ets domain
• Transforming protein C-ets-2

KeywordsUniProt

• DNA-binding
• Nucleus
• Phosphoprotein
• Proto-oncogene
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of ETS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TDP2
• CDK10
• COP1
• NFE2L2
• TP53