Seroatlas · Human Serome Atlas

KAT7

Histone acetyltransferase KAT7

Also known as: HBO1, HBOA, KAT7_HUMAN, MYST2, ZC2HC7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95251
Gene
KAT7
Ensembl
ENSG00000136504
Chromosome
17
Canonical length
611 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

611 residues, UniProt reviewed canonical sequence.

>O95251|KAT7
     1  MPRRKRNAGS SSDGTEDSDF STDLEHTDSS ESDGTSRRSA RVTRSSARLS QSSQDSSPVR
    61  NLQSFGTEEP AYSTRRVTRS QQQPTPVTPK KYPLRQTRSS GSETEQVVDF SDRETKNTAD
   121  HDESPPRTPT GNAPSSESDI DISSPNVSHD ESIAKDMSLK DSGSDLSHRP KRRRFHESYN
   181  FNMKCPTPGC NSLGHLTGKH ERHFSISGCP LYHNLSADEC KVRAQSRDKQ IEERMLSHRQ
   241  DDNNRHATRH QAPTERQLRY KEKVAELRKK RNSGLSKEQK EKYMEHRQTY GNTREPLLEN
   301  LTSEYDLDLF RRAQARASED LEKLRLQGQI TEGSNMIKTI AFGRYELDTW YHSPYPEEYA
   361  RLGRLYMCEF CLKYMKSQTI LRRHMAKCVW KHPPGDEIYR KGSISVFEVD GKKNKIYCQN
   421  LCLLAKLFLD HKTLYYDVEP FLFYVMTEAD NTGCHLIGYF SKEKNSFLNY NVSCILTMPQ
   481  YMRQGYGKML IDFSYLLSKV EEKVGSPERP LSDLGLISYR SYWKEVLLRY LHNFQGKEIS
   541  IKEISQETAV NPVDIVSTLQ ALQMLKYWKG KHLVLKRQDL IDEWIAKEAK RSNSNKTMDP
   601  SCLKWTPPKG T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KAT7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 48 nTPM
  • testis: 45 nTPM
  • parathyroid gland: 36 nTPM
  • skeletal muscle: 29 nTPM
  • tongue: 29 nTPM
  • thyroid gland: 28 nTPM

Single-cell type

  • late primary spermatocytes: 109 nCPM
  • podocytes: 88 nCPM
  • neutrophils: 78 nCPM
  • neutrophil progenitors: 75 nCPM
  • thymic myoid cells: 67 nCPM
  • erythrocyte progenitors: 65 nCPM

Immune cell

  • basophil: 19 nTPM
  • NK-cell: 16 nTPM
  • MAIT T-cell: 16 nTPM
  • naive CD4 T-cell: 14 nTPM
  • gdT-cell: 13 nTPM
  • eosinophil: 12 nTPM

Brain region

  • choroid plexus: 43 nTPM
  • cerebellum: 41 nTPM
  • hypothalamus: 39 nTPM
  • basal ganglia: 37 nTPM
  • cerebral cortex: 37 nTPM
  • white matter: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.13
gnomAD pLI
1
gnomAD missense Z
4.28
DepMap mean gene effect
-0.37
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KAT7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KAT7 as an antibody target. Whether an autoantibody or antibody against KAT7 could matter depends on whether native KAT7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KAT7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KAT7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KAT7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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