Seroatlas · Human Serome Atlas

SPIB

Transcription factor Spi-B

Also known as: SPI-B, SPIB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q01892
Gene: SPIB
Ensembl: ENSG00000269404
Chromosome: 19
Canonical length: 262 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q01892|SPIB
     1  MLALEAAQLD GPHFSCLYPD GVFYDLDSCK HSSYPDSEGA PDSLWDWTVA PPVPATPYEA
    61  FDPAAAAFSH PQAAQLCYEP PTYSPAGNLE LAPSLEAPGP GLPAYPTENF ASQTLVPPAY
   121  APYPSPVLSE EEDLPLDSPA LEVSDSESDE ALVAGPEGKG SEAGTRKKLR LYQFLLGLLT
   181  RGDMRECVWW VEPGAGVFQF SSKHKELLAR RWGQQKGNRK RMTYQKLARA LRNYAKTGEI
   241  RKVKRKLTYQ FDSALLPAVR RA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPIB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 93 nTPM

Expression across tissuesHPA

Tissue

tonsil: 93 nTPM
lymph node: 82 nTPM
appendix: 40 nTPM
spleen: 27 nTPM
small intestine: 25 nTPM
colon: 21 nTPM

Single-cell type

pdcs: 250 nCPM
tuft cells: 231 nCPM
colonocytes: 90 nCPM
b-cells: 66 nCPM
paneth cells: 31 nCPM
enteric transient amplifying cells: 30 nCPM

Immune cell

plasmacytoid DC: 574 nTPM
memory B-cell: 309 nTPM
naive B-cell: 262 nTPM
total PBMC: 15 nTPM
myeloid DC: 7 nTPM
NK-cell: 3.9 nTPM

Brain region

medulla oblongata: 5.9 nTPM
white matter: 4.8 nTPM
cerebellum: 4.5 nTPM
cerebral cortex: 4 nTPM
hypothalamus: 3.8 nTPM
pons: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.91
gnomAD missense Z: 1.26
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPIB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPIB as an antibody target. Whether an autoantibody or antibody against SPIB could matter depends on whether native SPIB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPIB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPIB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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