Seroatlas · Human Serome Atlas

TADA2B

Transcriptional adapter 2-beta

Also known as: MGC21874, TAD2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86TJ2
Gene
TADA2B
Ensembl
ENSG00000173011
Chromosome
4
Canonical length
420 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nuclear speckles

OverviewNCBI Gene

TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]

Canonical amino-acid sequenceUniProt

420 residues, UniProt reviewed canonical sequence.

>Q86TJ2|TADA2B
     1  MAELGKKYCV YCLAEVSPLR FRCTECQDIE LCPECFSAGA EIGHHRRYHG YQLVDGGRFT
    61  LWGPEAEGGW TSREEQLLLD AIEQFGFGNW EDMAAHVGAS RTPQEVMEHY VSMYIHGNLG
   121  KACIPDTIPN RVTDHTCPSG GPLSPSLTTP LPPLDISVAE QQQLGYMPLR DDYEIEYDQD
   181  AETLISGLSV NYDDDDVEIE LKRAHVDMYV RKLKERQRRK NIARDYNLVP AFLGKDKKEK
   241  EKALKRKITK EEKELRLKLR PLYQFMSCKE FDDLFENMHK EKMLRAKIRE LQRYRRNGIT
   301  KMEESAEYEA ARHKREKRKE NKNLAGSKRG KEDGKDSEFA AIENLPGFEL LSDREKVLCS
   361  SLNLSPARYV TVKTIIIKDH LQKRQGIPSK SRLPSYLDKV LKKRILNFLT ESGWISRDAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TADA2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 48 nTPM
  • tongue: 40 nTPM
  • bone marrow: 33 nTPM
  • pancreas: 29 nTPM
  • salivary gland: 23 nTPM
  • heart muscle: 19 nTPM

Single-cell type

  • late spermatids: 79 nCPM
  • thymic myoid cells: 37 nCPM
  • neutrophils: 36 nCPM
  • retinal pigment epithelial cells: 30 nCPM
  • rod photoreceptor cells: 29 nCPM
  • breast lactating cells: 26 nCPM

Immune cell

  • eosinophil: 6.9 nTPM
  • neutrophil: 4.3 nTPM
  • gdT-cell: 2.7 nTPM
  • memory CD8 T-cell: 2.6 nTPM
  • memory B-cell: 2.5 nTPM
  • naive CD4 T-cell: 2.3 nTPM

Brain region

  • hippocampal formation: 28 nTPM
  • cerebral cortex: 26 nTPM
  • cerebellum: 24 nTPM
  • pons: 23 nTPM
  • choroid plexus: 22 nTPM
  • thalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.72
gnomAD missense Z
2.8
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TADA2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TADA2B as an antibody target. Whether an autoantibody or antibody against TADA2B could matter depends on whether native TADA2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TADA2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TADA2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TADA2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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