Seroatlas · Human Serome Atlas

ELF3

ETS-related transcription factor Elf-3

Also known as: ELF3_HUMAN, EPR-1, ERT, ESE-1, ESX

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P78545
Gene
ELF3
Ensembl
ENSG00000163435
Chromosome
1
Canonical length
371 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in inflammatory response; negative regulation of DNA-templated transcription; and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

371 residues, UniProt reviewed canonical sequence.

>P78545|ELF3
     1  MAATCEISNI FSNYFSAMYS SEDSTLASVP PAATFGADDL VLTLSNPQMS LEGTEKASWL
    61  GEQPQFWSKT QVLDWISYQV EKNKYDASAI DFSRCDMDGA TLCNCALEEL RLVFGPLGDQ
   121  LHAQLRDLTS SSSDELSWII ELLEKDGMAF QEALDPGPFD QGSPFAQELL DDGQQASPYH
   181  PGSCGAGAPS PGSSDVSTAG TGASRSSHSS DSGGSDVDLD PTDGKLFPSD GFRDCKKGDP
   241  KHGKRKRGRP RKLSKEYWDC LEGKKSKHAP RGTHLWEFIR DILIHPELNE GLMKWENRHE
   301  GVFKFLRSEA VAQLWGQKKK NSNMTYEKLS RAMRYYYKRE ILERVDGRRL VYKFGKNSSG
   361  WKEEEVLQSR N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
229 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 229 nTPM
  • urinary bladder: 154 nTPM
  • colon: 151 nTPM
  • salivary gland: 140 nTPM
  • small intestine: 137 nTPM
  • duodenum: 135 nTPM

Single-cell type

  • esophageal apical cells: 4,005 nCPM
  • prostatic club cells: 1,510 nCPM
  • colonocytes: 1,284 nCPM
  • urothelial cells: 1,276 nCPM
  • prostatic hillock cells: 1,267 nCPM
  • goblet cells: 1,187 nCPM

Immune cell

  • neutrophil: 0.2 nTPM
  • basophil: 0.1 nTPM
  • myeloid DC: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebellum: 3.1 nTPM
  • cerebral cortex: 2.4 nTPM
  • choroid plexus: 2.1 nTPM
  • basal ganglia: 2 nTPM
  • hypothalamus: 2 nTPM
  • white matter: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
1.88
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELF3 as an antibody target. Whether an autoantibody or antibody against ELF3 could matter depends on whether native ELF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ELF3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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