Seroatlas · Human Serome Atlas

ETS1

Protein C-ets-1

Also known as: ETS-1, ETS1_HUMAN, EWSR2, FLJ10768

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P14921
Gene
ETS1
Ensembl
ENSG00000134954
Chromosome
11
Canonical length
441 aa
Protein class
Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins, Transcription factors
Subcellular location
Nucleoplasm
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>P14921|ETS1
     1  MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK ATFSGFTKEQ
    61  QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM NGAALCALGK DCFLELAPDF
   121  VGDILWEHLE ILQKEDVKPY QVNGVNPAYP ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF
   181  ITESYQTLHP ISSEELLSLK YENDYPSVIL RDPLQTDTLQ NDYFAIKQEV VTPDNMCMGR
   241  TSRGKLGGQD SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP
   301  KGTFKDYVRD RADLNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC QSFISWTGDG
   361  WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN IIHKTAGKRY VYRFVCDLQS
   421  LLGYTPEELH AMLDVKPDAD E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ETS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
253 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 253 nTPM
  • lymph node: 215 nTPM
  • tonsil: 196 nTPM
  • spleen: 143 nTPM
  • appendix: 110 nTPM
  • adipose tissue: 82 nTPM

Single-cell type

  • t-cells: 739 nCPM
  • nk-cells: 689 nCPM
  • vascular endothelial cells: 391 nCPM
  • innate lymphoid cells: 388 nCPM
  • melanocytes: 279 nCPM
  • lymphatic endothelial cells: 249 nCPM

Immune cell

  • basophil: 44 nTPM
  • T-reg: 32 nTPM
  • naive CD4 T-cell: 31 nTPM
  • MAIT T-cell: 28 nTPM
  • memory CD4 T-cell: 26 nTPM
  • NK-cell: 26 nTPM

Brain region

  • thalamus: 21 nTPM
  • midbrain: 20 nTPM
  • pons: 18 nTPM
  • medulla oblongata: 17 nTPM
  • cerebral cortex: 16 nTPM
  • spinal cord: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ETS1.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 48 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • 11q partial monosomy syndrome
  • ETS1-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.78
gnomAD missense Z
2.52
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ETS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ETS1 as an antibody target. Whether an autoantibody or antibody against ETS1 could matter depends on whether native ETS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ETS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ETS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ETS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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