Seroatlas · Human Serome Atlas

ELF5

ETS-related transcription factor Elf-5

Also known as: ELF5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKW6
Gene: ELF5
Ensembl: ENSG00000135374
Chromosome: 11
Canonical length: 265 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes an epithelium-specific ETS family transcription factor. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. This gene has been implicated as a tumor suppressive transcription factor in breast cancer. [provided by RefSeq, May 2022]

Canonical amino-acid sequenceUniProt

265 residues, UniProt reviewed canonical sequence.

>Q9UKW6|ELF5
     1  MPSLPHSHRV MLDSVTHSTF LPNASFCDPL MSWTDLFSNE EYYPAFEHQT ACDSYWTSVH
    61  PEYWTKRHVW EWLQFCCDQY KLDTNCISFC NFNISGLQLC SMTQEEFVEA AGLCGEYLYF
   121  ILQNIRTQGY SFFNDAEESK ATIKDYADSN CLKTSGIKSQ DCHSHSRTSL QSSHLWEFVR
   181  DLLLSPEENC GILEWEDREQ GIFRVVKSEA LAKMWGQRKK NDRMTYEKLS RALRYYYKTG
   241  ILERVDRRLV YKFGKNAHGW QEDKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELF5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 141 nTPM

Expression across tissuesHPA

Tissue

breast: 141 nTPM
salivary gland: 139 nTPM
seminal vesicle: 29 nTPM
kidney: 16 nTPM
lung: 7.1 nTPM
skin: 6.3 nTPM

Single-cell type

breast lactating cells: 1,231 nCPM
lacrimal acinar cells: 241 nCPM
salivary acinar cells: 208 nCPM
renal collecting duct principal cells: 198 nCPM
breast secretory cells: 140 nCPM
papillary tip epithelial cells: 82 nCPM

Immune cell

basophil: 0.4 nTPM
intermediate monocyte: 0.3 nTPM
non-classical monocyte: 0.3 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

choroid plexus: 1.5 nTPM
amygdala: 1 nTPM
cerebellum: 1 nTPM
basal ganglia: 0.9 nTPM
cerebral cortex: 0.9 nTPM
hippocampal formation: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELF5 as an antibody target. Whether an autoantibody or antibody against ELF5 could matter depends on whether native ELF5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELF5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELF5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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