Seroatlas · Human Serome Atlas

H1-10

Histone H1.10

Also known as: H1FX, H1X, H1X_HUMAN, MGC15959, MGC8350

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92522
Gene
H1-10
Ensembl
ENSG00000184897
Chromosome
3
Canonical length
213 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>Q92522|H1-10
     1  MSVELEEALP VTTAEGMAKK VTKAGGSAAL SPSKKRKNSK KKNQPGKYSQ LVVETIRRLG
    61  ERNGSSLAKI YTEAKKVPWF DQQNGRTYLK YSIKALVQND TLLQVKGTGA NGSFKLNRKK
   121  LEGGGERRGA PAAATAPAPT AHKAKKAAPG AAGSRRADKK PARGQKPEQR SHKKGAGAKK
   181  DKGGKAKKTA AAGGKKVKKA AKPSVPKVPK GRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H1-10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
949 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 949 nTPM
  • skin: 245 nTPM
  • cerebellum: 159 nTPM
  • ovary: 159 nTPM
  • breast: 138 nTPM
  • cervix: 138 nTPM

Single-cell type

  • epididymal basal cells: 770 nCPM
  • plasma cells: 702 nCPM
  • monocyte progenitors: 371 nCPM
  • innate lymphoid cells: 348 nCPM
  • erythrocyte progenitors: 342 nCPM
  • breast myoepithelial cells: 319 nCPM

Immune cell

  • eosinophil: 18 nTPM
  • plasmacytoid DC: 11 nTPM
  • naive CD4 T-cell: 8.4 nTPM
  • myeloid DC: 7.9 nTPM
  • memory CD4 T-cell: 6.8 nTPM
  • T-reg: 6.1 nTPM

Brain region

  • cerebellum: 154 nTPM
  • hypothalamus: 130 nTPM
  • cerebral cortex: 129 nTPM
  • white matter: 125 nTPM
  • basal ganglia: 118 nTPM
  • hippocampal formation: 109 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H1-10.

Disease | ImmuneIEDB

Conditions an epitope on H1-10 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.35
gnomAD pLI
0.09
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of H1-10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H1-10 as an antibody target. Whether an autoantibody or antibody against H1-10 could matter depends on whether native H1-10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H1-10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H1-10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H1-10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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