Seroatlas · Protein domains

SKP1/BTB/POZ domain superfamily

IPR011333

Definition

The BTB (for BR-C, ttk and bab) PMID:7938017 or POZ (for Pox virus and Zinc finger) [[cite:PMID:7958847], [cite:PMID:17384421]] domain is a versatile protein-protein interaction motif involved in many cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination PMID:16207353. The BTB domain can occur alongside other domains: BTB-zinc finger (BTB-ZF), BTB-BACK-Kelch (BBK), voltage-gated potassium channel T1 (T1-Kv) PMID:9917379, MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP). Other proteins, such as Skp1 and ElonginC, consist almost exclusively of the core BTB fold. In all of these protein families, the BTB core fold is structurally conserved, consisting of a 2-layer α/β topology where a cluster of α-helices is flanked by short β-sheets PMID:9770450. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [[cite:PMID:9019154], [cite:PMID:9824158], [cite:PMID:9765306]]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN. This entry includes the BTB/POZ domain, as well as Skp1 N-terminal region which has an α/β structure similar to that of the BTB/POZ domain fold [[cite:PMID:9917379], [cite:PMID:11099048]].

189 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (189 proteins: gene, accession, name)

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