ZNF131
Zinc finger protein 131
Also known as: pHZ-10, ZBTB35, ZN131_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P52739
- Gene
- ZNF131
- Ensembl
- ENSG00000172262
- Chromosome
- 5
- Canonical length
- 623 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Intermediate filaments
OverviewNCBI Gene
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Located in intermediate filament cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
623 residues, UniProt reviewed canonical sequence.
>P52739|ZNF131
1 MEAEETMECL QEFPEHHKMI LDRLNEQREQ DRFTDITLIV DGHHFKAHKA VLAACSKFFY
61 KFFQEFTQEP LVEIEGVSKM AFRHLIEFTY TAKLMIQGEE EANDVWKAAE FLQMLEAIKA
121 LEVRNKENSA PLEENTTGKN EAKKRKIAET SNVITESLPS AESEPVEIEV EIAEGTIEVE
181 DEGIETLEEV ASAKQSVKYI QSTGSSDDSA LALLADITSK YRQGDRKGQI KEDGCPSDPT
241 SKQVEGIEIV ELQLSHVKDL FHCEKCNRSF KLFYHFKEHM KSHSTESFKC EICNKRYLRE
301 SAWKQHLNCY HLEEGGVSKK QRTGKKIHVC QYCEKQFDHF GHFKEHLRKH TGEKPFECPN
361 CHERFARNST LKCHLTACQT GVGAKKGRKK LYECQVCNSV FNSWDQFKDH LVIHTGDKPN
421 HCTLCDLWFM QGNELRRHLS DAHNISERLV TEEVLSVETR VQTEPVTSMT IIEQVGKVHV
481 LPLLQVQVDS AQVTVEQVHP DLLQDSQVHD SHMSELPEQV QVSYLEVGRI QTEEGTEVHV
541 EELHVERVNQ MPVEVQTELL EADLDHVTPE IMNQEERESS QADAAEAARE DHEDAEDLET
601 KPTVDSEAEK AENEDRTALP VLELocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF131 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 26 nTPM
Expression across tissuesHPA
Tissue
- testis: 26 nTPM
- bone marrow: 22 nTPM
- thymus: 21 nTPM
- cerebellum: 18 nTPM
- breast: 16 nTPM
- lymph node: 16 nTPM
Single-cell type
- myonuclei: 283 nCPM
- thymocytes: 241 nCPM
- neutrophils: 193 nCPM
- somatotrophs: 181 nCPM
- hematopoietic stem cells: 180 nCPM
- megakaryocyte-erythroid progenitors: 173 nCPM
Immune cell
- naive CD4 T-cell: 22 nTPM
- gdT-cell: 19 nTPM
- MAIT T-cell: 19 nTPM
- memory CD4 T-cell: 18 nTPM
- memory CD8 T-cell: 18 nTPM
- naive CD8 T-cell: 18 nTPM
Brain region
- cerebellum: 27 nTPM
- white matter: 20 nTPM
- cerebral cortex: 20 nTPM
- hippocampal formation: 17 nTPM
- thalamus: 17 nTPM
- hypothalamus: 17 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.16
- gnomAD pLI
- 1
- gnomAD missense Z
- 2.67
- DepMap mean gene effect
- -1.11
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of transcription by RNA polymerase II
- regulation of cytokine production
- regulation of immune system process
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZNF131 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF131 as an antibody target. Whether an autoantibody or antibody against ZNF131 could matter depends on whether native ZNF131 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF131 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF131 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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