Seroatlas · Human Serome Atlas

KCNG1

Voltage-gated potassium channel regulatory subunit KCNG1

Also known as: K13, KCNG, KCNG1_HUMAN, kH2, Kv6.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UIX4
Gene: KCNG1
Ensembl: ENSG00000026559
Chromosome: 20
Canonical length: 513 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Subcellular location: Vesicles

OverviewNCBI Gene

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

513 residues, UniProt reviewed canonical sequence.

>Q9UIX4|KCNG1
     1  MTLLPGDNSD YDYSALSCTS DASFHPAFLP QRQAIKGAFY RRAQRLRPQD EPRQGCQPED
    61  RRRRIIINVG GIKYSLPWTT LDEFPLTRLG QLKACTNFDD ILNVCDDYDV TCNEFFFDRN
   121  PGAFGTILTF LRAGKLRLLR EMCALSFQEE LLYWGIAEDH LDGCCKRRYL QKIEEFAEMV
   181  EREEEDDALD SEGRDSEGPA EGEGRLGRCM RRLRDMVERP HSGLPGKVFA CLSVLFVTVT
   241  AVNLSVSTLP SLREEEEQGH CSQMCHNVFI VESVCVGWFS LEFLLRLIQA PSKFAFLRSP
   301  LTLIDLVAIL PYYITLLVDG AAAGRRKPGA GNSYLDKVGL VLRVLRALRI LYVMRLARHS
   361  LGLQTLGLTA RRCTREFGLL LLFLCVAIAL FAPLLYVIEN EMADSPEFTS IPACYWWAVI
   421  TMTTVGYGDM VPRSTPGQVV ALSSILSGIL LMAFPVTSIF HTFSRSYLEL KQEQERVMFR
   481  RAQFLIKTKS QLSVSQDSDI LFGSASSDTR DNN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 80 nTPM

Expression across tissuesHPA

Tissue

endometrium: 80 nTPM
cervix: 50 nTPM
fallopian tube: 18 nTPM
cerebral cortex: 12 nTPM
seminal vesicle: 12 nTPM
amygdala: 11 nTPM

Single-cell type

syncytiotrophoblasts: 109 nCPM
cytotrophoblasts: 73 nCPM
esophageal apical cells: 36 nCPM
late spermatids: 35 nCPM
late primary spermatocytes: 26 nCPM
endometrial luminal cells: 24 nCPM

Immune cell

naive B-cell: 7.1 nTPM
memory B-cell: 0.3 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

midbrain: 113 nTPM
medulla oblongata: 70 nTPM
basal ganglia: 63 nTPM
cerebral cortex: 53 nTPM
amygdala: 42 nTPM
hippocampal formation: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0.03
gnomAD missense Z: 4.28
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNG1 as an antibody target. Whether an autoantibody or antibody against KCNG1 could matter depends on whether native KCNG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNG1 is annotated at the cell surface, where native KCNG1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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