Seroatlas · Human Serome Atlas

HIC1

Hypermethylated in cancer 1 protein

Also known as: HIC1_HUMAN, ZBTB29, ZNF901

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14526
Gene: HIC1
Ensembl: ENSG00000177374
Chromosome: 17
Canonical length: 733 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

733 residues, UniProt reviewed canonical sequence.

>Q14526|HIC1
     1  MTFPEADILL KSGECAGQTM LDTMEAPGHS RQLLLQLNNQ RTKGFLCDVI IVVQNALFRA
    61  HKNVLAASSA YLKSLVVHDN LLNLDHDMVS PAVFRLVLDF IYTGRLADGA EAAAAAAVAP
   121  GAEPSLGAVL AAASYLQIPD LVALCKKRLK RHGKYCHLRG GGGGGGGYAP YGRPGRGLRA
   181  ATPVIQACYP SPVGPPPPPA AEPPSGPEAA VNTHCAELYA SGPGPAAALC ASERRCSPLC
   241  GLDLSKKSPP GSAAPERPLA ERELPPRPDS PPSAGPAAYK EPPLALPSLP PLPFQKLEEA
   301  APPSDPFRGG SGSPGPEPPG RPDGPSLLYR WMKHEPGLGS YGDELGRERG SPSERCEERG
   361  GDAAVSPGGP PLGLAPPPRY PGSLDGPGAG GDGDDYKSSS EETGSSEDPS PPGGHLEGYP
   421  CPHLAYGEPE SFGDNLYVCI PCGKGFPSSE QLNAHVEAHV EEEEALYGRA EAAEVAAGAA
   481  GLGPPFGGGG DKVAGAPGGL GELLRPYRCA SCDKSYKDPA TLRQHEKTHW LTRPYPCTIC
   541  GKKFTQRGTM TRHMRSHLGL KPFACDACGM RFTRQYRLTE HMRIHSGEKP YECQVCGGKF
   601  AQQRNLISHM KMHAVGGAAG AAGALAGLGG LPGVPGPDGK GKLDFPEGVF AVARLTAEQL
   661  SLKQQDKAAA AELLAQTTHF LHDPKVALES LYPLAKFTAE LGLSPDKAAE VLSQGAHLAA
   721  GPDGRTIDRF SPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HIC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

ovary: 26 nTPM
endometrium: 24 nTPM
cervix: 23 nTPM
heart muscle: 22 nTPM
fallopian tube: 22 nTPM
adipose tissue: 22 nTPM

Single-cell type

pericytes: 67 nCPM
leydig cells: 64 nCPM
fibroblasts: 56 nCPM
peritubular myoid cells: 52 nCPM
lymphatic endothelial cells: 40 nCPM
decidual stromal cells: 35 nCPM

Immune cell

eosinophil: 1.9 nTPM
intermediate monocyte: 0.6 nTPM
non-classical monocyte: 0.2 nTPM
naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

medulla oblongata: 15 nTPM
thalamus: 15 nTPM
amygdala: 14 nTPM
midbrain: 13 nTPM
pons: 12 nTPM
spinal cord: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0.13
gnomAD missense Z: 2.7
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HIC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HIC1 as an antibody target. Whether an autoantibody or antibody against HIC1 could matter depends on whether native HIC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HIC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HIC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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