KCTD15
BTB/POZ domain-containing protein KCTD15
Also known as: KCD15_HUMAN, MGC25497
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96SI1
- Gene
- KCTD15
- Ensembl
- ENSG00000153885
- Chromosome
- 19
- Canonical length
- 283 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
- Quaternary structure
- Homopentamer
OverviewNCBI Gene
Enables identical protein binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
283 residues, UniProt reviewed canonical sequence.
>Q96SI1|KCTD15
1 MPHRKERPSG SSLHTHGSTG TAEGGNMSRL SLTRSPVSPL AAQGIPLPAQ LTKSNAPVHI
61 DVGGHMYTSS LATLTKYPDS RISRLFNGTE PIVLDSLKQH YFIDRDGEIF RYVLSFLRTS
121 KLLLPDDFKD FSLLYEEARY YQLQPMVREL ERWQQEQEQR RRSRACDCLV VRVTPDLGER
181 IALSGEKALI EEVFPETGDV MCNSVNAGWN QDPTHVIRFP LNGYCRLNSV QVLERLFQRG
241 FSVAASCGGG VDSSQFSEYV LCREERRPQP TPTAVRIKQE PLDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KCTD15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.42
- Highest tissue expression
- 75 nTPM
Expression across tissuesHPA
Tissue
- skin: 75 nTPM
- pancreas: 22 nTPM
- smooth muscle: 21 nTPM
- esophagus: 21 nTPM
- endometrium: 21 nTPM
- seminal vesicle: 19 nTPM
Single-cell type
- astrocytes: 68 nCPM
- bergmann glia: 39 nCPM
- smooth muscle cells: 30 nCPM
- cone photoreceptor cells: 29 nCPM
- ependymal cells: 27 nCPM
- rod photoreceptor cells: 26 nCPM
Immune cell
- eosinophil: 6.1 nTPM
- non-classical monocyte: 5 nTPM
- intermediate monocyte: 3.3 nTPM
- myeloid DC: 2.5 nTPM
- classical monocyte: 1.7 nTPM
- memory CD4 T-cell: 0.8 nTPM
Brain region
- midbrain: 54 nTPM
- thalamus: 52 nTPM
- hypothalamus: 52 nTPM
- amygdala: 50 nTPM
- hippocampal formation: 49 nTPM
- basal ganglia: 47 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.88
- gnomAD pLI
- 0.04
- gnomAD missense Z
- 1.17
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of KCTD15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KCTD15 as an antibody target. Whether an autoantibody or antibody against KCTD15 could matter depends on whether native KCTD15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KCTD15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label KCTD15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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