Seroatlas · Human Serome Atlas

KLHL34

Kelch-like protein 34

Also known as: FLJ34960, KLH34_HUMAN, RP11-450P7.3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N239
Gene: KLHL34
Ensembl: ENSG00000185915
Chromosome: X
Canonical length: 644 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

644 residues, UniProt reviewed canonical sequence.

>Q8N239|KLHL34
     1  MSYFLSYCKA HGGALLTGYQ ALRAEGFLCD VTLETEGSEF PAHRSLLACS SDYFRALFKS
    61  HTQESRARVI HLHVPSAAGL QRLLDFIYTA WLSLSMDTVE DTLEAASYLQ VTEALGLCGR
   121  YLERQLAPEN CCFAANVAAR FGLAHTLDAA ERCIVSHLQE LLARGAGPAG LLELNPTSLR
   181  AVLGAPDVAR VPEARLLGLA LAWLRQEPTT ERLAHCTELL ERVRFGLVPA DVLRRVYSGS
   241  GLVLPARVKG LIIQALNYHT TPSRQPLMQG EQTSIRSPQT RILLVGGRRA REVVIEEVAA
   301  PQRAARGQVA APEPEEEEEE LEEEEEEEEW ELTQNVVAFD VYNHRWRSLT QLPTPLLGHS
   361  VCTAGNFLFV LGGESPSGSA SSPLADDSRV VTAQVHRYDP RFHAWTEVPA MREARAHFWC
   421  GAVGERLLAV GGLGAGGEVL ASVEMYDLRR DRWTAAGALP RALHGHAGAV GDRGVVYISG
   481  GKAGRGEGGA SSLRDLYVLG PEEQVWSKKA PMGTARFGHH MAVLRGAVFA FLGRYEPFSE
   541  IERYDPGADQ WTRLRPLPYD RFCYGLAVVE ETALLLGGLK WRDSRQVPTR NVVGYDLDLD
   601  RWEDIGCALP WAWSGLRCAV LQLAEGGDDE REGEVGEALD LVLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 24 nTPM
retina: 3 nTPM
tongue: 1.9 nTPM
heart muscle: 1.7 nTPM
cerebellum: 1 nTPM
duodenum: 1 nTPM

Single-cell type

rod photoreceptor cells: 32 nCPM
retinal amacrine cells: 18 nCPM
retinal ganglion cells: 12 nCPM
brain excitatory neurons: 11 nCPM
cone photoreceptor cells: 10 nCPM
myonuclei: 8.8 nCPM

Immune cell

naive CD4 T-cell: 0.6 nTPM
memory CD4 T-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM
memory B-cell: 0.1 nTPM
T-reg: 0.1 nTPM
total PBMC: 0.1 nTPM

Brain region

cerebral cortex: 10 nTPM
hippocampal formation: 9.3 nTPM
amygdala: 9 nTPM
cerebellum: 8.3 nTPM
basal ganglia: 6.1 nTPM
white matter: 4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 1.46
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL34 as an antibody target. Whether an autoantibody or antibody against KLHL34 could matter depends on whether native KLHL34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL34 is annotated as secreted, so native KLHL34 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label KLHL34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...