Seroatlas · Human Serome Atlas

KLHL18

Kelch-like protein 18

Also known as: FLJ13703, KIAA0795, KLH18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O94889
Gene
KLHL18
Ensembl
ENSG00000114648
Chromosome
3
Canonical length
574 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of mitotic cell cycle phase transition and protein ubiquitination. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

574 residues, UniProt reviewed canonical sequence.

>O94889|KLHL18
     1  MVEDGAEELE DLVHFSVSEL PSRGYGVMEE IRRQGKLCDV TLKIGDHKFS AHRIVLAASI
    61  PYFHAMFTND MMECKQDEIV MQGMDPSALE ALINFAYNGN LAIDQQNVQS LLMGASFLQL
   121  QSIKDACCTF LRERLHPKNC LGVRQFAETM MCAVLYDAAN SFIHQHFVEV SMSEEFLALP
   181  LEDVLELVSR DELNVKSEEQ VFEAALAWVR YDREQRGPYL PELLSNIRLP LCRPQFLSDR
   241  VQQDDLVRCC HKCRDLVDEA KDYHLMPERR PHLPAFRTRP RCCTSIAGLI YAVGGLNSAG
   301  DSLNVVEVFD PIANCWERCR PMTTARSRVG VAVVNGLLYA IGGYDGQLRL STVEAYNPET
   361  DTWTRVGSMN SKRSAMGTVV LDGQIYVCGG YDGNSSLSSV ETYSPETDKW TVVTSMSSNR
   421  SAAGVTVFEG RIYVSGGHDG LQIFSSVEHY NHHTATWHPA AGMLNKRCRH GAASLGSKMF
   481  VCGGYDGSGF LSIAEMYSSV ADQWCLIVPM HTRRSRVSLV ASCGRLYAVG GYDGQSNLSS
   541  VEMYDPETDC WTFMAPMACH EGGVGVGCIP LLTI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • retina: 19 nTPM
  • bone marrow: 15 nTPM
  • skin: 13 nTPM
  • cerebellum: 9.2 nTPM
  • spleen: 8.4 nTPM
  • esophagus: 8.2 nTPM

Single-cell type

  • retinal bipolar cells: 162 nCPM
  • neutrophils: 159 nCPM
  • rod photoreceptor cells: 144 nCPM
  • microglia: 115 nCPM
  • endometrial stromal cells: 111 nCPM
  • neutrophil progenitors: 108 nCPM

Immune cell

  • non-classical monocyte: 19 nTPM
  • classical monocyte: 12 nTPM
  • intermediate monocyte: 11 nTPM
  • myeloid DC: 7.8 nTPM
  • basophil: 6.2 nTPM
  • total PBMC: 5.7 nTPM

Brain region

  • cerebral cortex: 16 nTPM
  • hypothalamus: 14 nTPM
  • basal ganglia: 14 nTPM
  • white matter: 13 nTPM
  • midbrain: 13 nTPM
  • cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.08
gnomAD missense Z
2.01
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLHL18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL18 as an antibody target. Whether an autoantibody or antibody against KLHL18 could matter depends on whether native KLHL18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLHL18. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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